Cerebral Hemorrhage
Conditions
Interventions
Placebo:Placebo
Atorvastatin:Atorvastatin 20mg, QN
Dexamethasone:Dexamethasone 0.75mg, tid
Atorvastatin&Dexamethasone:Atorvastatin 20mg, QN & Dexamethasone 0.75mg, tid
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years male and female; 2. GCS> 8, head CT or MRI clearly shows spontaneous intracerebral hematoma (hematoma volume less than 30ml); 3. Hematoma occurs less than 72 hours; 4. Take non-surgical treatment; 5. The patient has been acknowledge of the nature of the study, and volunteer to participate in the trial and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patient who is allergic to the drug contents or other statins; 2. Within 72 hours, required surgical treatment due to the increased bleeding; 3. Hematomas cause herniation or can be highly suspected of causing herniation, non-surgical incurable; 4. Hematoma is caused by tumors, blood diseases, arteriovenous structural lesions such as aneurysms, arteriovenous malformations and various sinus fistulas; 5. Obvious abnormal function of liver and kidney before the trial, affecting the overall prognosis of patient; 6 patient with oral statin history within 2 weeks before the experiment; 7. 4 weeks before the experiment with oral steroid patients; 8. In the past 4 weeks, taking aspirin and other antiplatelet drugs such as warfarin and other anticoagulants; 9. Patient who has participated in other drug clinical trials in 4 weeks 10. Pregnancy or lactation patients; 11. Patient with poor compliance, and cannot complete the study according to the research program; 12. The researcher finds there is any situation that is not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Haematoma Absorptance Velocity;Extinction rate of edama;Changing of Neurosigns; | — |
Secondary
| Measure | Time frame |
|---|---|
| duration in the ICU;Glass Outcome Score (90 days after hospitalized); | — |
Countries
China
Contacts
Public ContactJiang Rongcai
Tianjin Medical University General Hospital
Outcome results
None listed