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The optimal effect-site concentration of remifentanil combined with sevoflurane anesthesia induction to prevent hypertensive reaction during endotracheal intubation without muscle relaxants: a prospective randomized controlled clinical trial in adults

The optimal effect-site concentration of remifentanil combined with sevoflurane anesthesia induction to prevent hypertensive reaction during endotracheal intubation without muscle relaxants: a prospective randomized controlled clinical trial in adults

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-TCS-13003154
Enrollment
Unknown
Registered
2013-04-09
Start date
2013-03-12
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypertension

Interventions

EC3:remifentanil 3 ng/ml
EC4:remifentanil 4 ng/ml
EC5:remifentanil 5 ng/ml
EC6:remifentanil 6 ng/ml

Sponsors

First affiliated Hospital of Xiamen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 55 Years

Inclusion criteria

Inclusion criteria: patients aged 1855 years with American Society of Anesthesiologists physical status I and II (ASA I-II), who underwent selective surgery.

Exclusion criteria

Exclusion criteria: Exclusion criteria were patients with hypertension, heart disease, pulmonary disease, liver/ renal disease, diabetes, neurological disease and mental disease; patients who were on long-term opiods or sedatives such as diazepam; patients with suspected difficult airway intubation Mallampati classification> grade 2, thyromental distance (TMD)140mmHg and/or diastolic blood pressure (DBP) >90 mmHg before intubation.

Design outcomes

Primary

MeasureTime frame
Heart rate;blood pressure;—

Countries

China

Contacts

Public ContactHaixing Luan
luanhaixing258@sina.com+86 0592 2139708

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026