Autoimmune Thyroiditis and Subclinical hypothyroidism during Pregnancy
Conditions
Interventions
Group B2:To be grouped depended on the TSH 2.5-10.0mIU/L, TPOAb=50IU/mL, and to be treated by natural control
Group C:To be grouped depended by TSH=100IU/mL, and to be treated by natural control.
Group A:To be grouped by TSH>10.0mIU/L, TPOAb>=50IU/mL, and to be treated by L-T4 replacement therapy.
Group B1:To be grouped by TSH>10.0mIU/L, TPOAb>=50IU/mL, and to be treated by L-T4 replacement therapy.
Group D:To be grouped by TSH 0.3-2.5mIU/L, TPOAb<50IU/mL, and to be treated by normal control.
Sponsors
China Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. gestational age fewer than 7 weeks; 2. Age: 15-70 years
Exclusion criteria
Exclusion criteria: 1. no personal history and family history of known genetic diseases; 2. no history of living in an iodine deficient area; 3. no personal thyroid disease history; 4. no other severe diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pregnant women: Serum TSH, TT4, FT4, TPOAb, TgAb, urine iodine and thyroid ultrasound;offspring: Serum TSH, FT4, TPOAb, urine iodine; | — |
Secondary
| Measure | Time frame |
|---|---|
| offspring: index of neuropsychological development; | — |
Countries
China
Contacts
Public ContactWeiping Teng
Outcome results
None listed