The digestive disease for usage of esomeprazole
Conditions
Interventions
ADR group:Take aomeprazole oral preparation
Non ADR group:Take aomeprazole oral preparation
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) patients who have been taking esomeprazole for 1 year; 2) aged between 18 and 60 years; 3) volunteer to participate in the experiment.
Exclusion criteria
Exclusion criteria: 1) apply omeprazole for more than one month before the test; 2) use other proton pump inhibitors for more than three months prior to the test; 3) abnormal calcium metabolism in the body; 4) bone disease and related risk factors; 5) or AST, ALT, BUN, Cr not more than twice the normal value; 6) or used other experimental drugs within one month prior to the inclusion of the test; 7) or not to be on time;Or patients who are using glucocorticoids; 8) or have severe heart, lung, liver and kidney dysfunction; 9) and the researchers think that it is not suitable for the candidate or the researcher who considers it inappropriate to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood calcium;BGP;B-ALP; bone mineral density;CYP2C19 genetic polymorphism; | — |
Countries
China
Contacts
Public ContactCheng Guo
Shanghai Jiao Tong University Affiliated Sixth People Hospital
Outcome results
None listed