The effect of epidural lidocaine on the depth of propofol general anesthesia and its mechanism

Higher lever of epidural blockade ,more powerfully,intensify sedative effects during induction of propofol general anesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-RRC-11001568

Enrollment

Unknown

Registered

2011-09-29

Start date

2011-03-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gastric or intestine surgery

Interventions

Total:epidural saline control group (Group C, L2-L3 puncture, saline), intravenous lidocaine group (Group IV, L2-L3 puncture, saline epidural, intravenous lidocaine 1mg/kg), epidural lidocaine group I

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Aged 25 -65 yr,weighing 45-85 kg, with ASA physical status I -II, undergoing gastric or intestine surgery were enrolled in this study.

Exclusion criteria

Exclusion criteria: Any history of cardiovascular, psychological or neurological diseases, alcohol abuse, long-term use of sedative drugs, opioids and liver enzyme induction or inhibition medicine.

Design outcomes

Primary

Measure	Time frame
The induction (BIS reach 60) doses of propofol;plasma concentration of propofol;	—

Secondary

Measure	Time frame
target effect site concentration of propofol(BIS reach 60);The BIS-values at different time points;plasma concentration of lidocaine;the induction time (BIS reach 60);The sensory block level after the epidural injection;	—

Countries

China

Contacts

Public ContactYan Xiang

xyhwh@hotmail.com+86 0571-87236164

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026