Coronary heart disease
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Patients undergoing coronary artery bypass graft surgery only Aged 18-70 years old Clopidogrel 75mg at least 5 days (or clopidogrel 300mg 8 hours) Agree to sign the informed consent.
Exclusion criteria
Exclusion criteria: Secondary surgery and emergency surgery patientsCombined with other operations (such as valve replacement or aortic surgery) patients; Severe liver and kidney function clinical diagnosis of heart and lung failure, or combined with other brain diseases; Trace hematocrit (Hct) <33%, platelets (Plt) <100X10^9/L; Clinical diagnosis coagulation abnormalities (such as warfarin, coagulation congenital abnormalities); For any reason can not cope with studies, such as the following: language comprehension, mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post-operative blood loss in 6 h and 24 h; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of MACE after discontinuing anti-platelet drugs;the incidence of mortality;Transfusion requirements;re-exploration rates;mechanical ventilation time;intensive care unit and in-hospital stays;Postoperative infection (incision, lungs);the total cost of hospitalization; | — |
Countries
China
Contacts
Fuwai Hospital, National Center of Cardiovascular, Chinese Academy of Medical Sciences and Peking Union Medical College