schizophrenia
Conditions
Interventions
paliperidone group:paliperidone
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Schizophrenic patients with diagnosis in accordance with (CCMD-III) criteria; 2. Without a history of substance abuse (like alcohol), past or present neurological disease, or any other organic; 3. disturbance that might have interfered with the aim of the study; 4. First-episode or neuroleptic-free schizophrenics, with more than 1 month of washout; 5. No other drugs were given except benzhexol for extrapyramidal adverse effects, and alprazolam for insomnia.
Exclusion criteria
Exclusion criteria: 1. Patients with hepatic or renal dysfunction or diabetes; 2. Patients with congenital long QT syndrome or arrhythmia; 3. Patients allergic to paliperidone; 4. Patients with a history of mental illness other than schizophrenia, such as epilepsy, dementia, alcoholism; 5. drug abuse, or clinically significant organic or neurological diseases; 6. Women with pregnancy, lactation or were pregnant during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| genotype;plasma concentrations of paliperidone; | — |
Countries
China
Contacts
Public ContactXu Ping
Outcome results
None listed