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The pathogenic mechanism and prevention strategy of high concentration blood glutamate in severe traumatic brain injury complicated lung injury

The mechanisms and Intervention of organ and system dysfunction after severe brain injury

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-RPC-15006770
Enrollment
Unknown
Registered
2015-07-19
Start date
2015-07-20
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain injury

Interventions

Hemofiltration treatment groups:Hemofiltration

Sponsors

Research Institute of Surgery and Daping Hospital, the Third Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Non-injury control group: the surgical patients with no trauma and brain damage; 2. No brain injury groups: moderate and severe trauma patients without the direct and indirect brain damage, mainly the severe organ dysfunction patients; 3. Brain injury group: mild, moderate, and severe stroke (including cerebral obstruction, cerebral hemorrhage, subarachnoid hemorrhage), and brain trauma patients; 4. Hemofiltration treatment groups: stroke and brain trauma patients with hemofiltration.

Exclusion criteria

Exclusion criteria: Heart failure, severe lung disease, renal failure in patients before acute stroke and brain trauma has occurred. Brainstem lesions involving the respiratory and circulatory center causing respiratory, circulatory disorders

Design outcomes

Primary

MeasureTime frame
glutamate;—

Countries

China

Contacts

Public ContactZhou Yuanguo
yuanguo.zhou@gmail.com+86 13608308776

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 24, 2026