systemic inflammatory response during cardiopulmonary bypass
Conditions
Interventions
Group CPB:No interventions
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 5 Years
Inclusion criteria
Inclusion criteria: 1. Group CPB are the children who have congenital ventricular septal defect (VSD) with or without atrial septal defect (ASD), aged 1~5 years old; 2. Control group are the children who have patent ductus arteriosus(PDA) without cardiopulmonary bypass,aged 1~5 years old; 3. Children who have no operative contraindications; 4. No other special history:hematopoietic System Disease, hereditary metabolic disease and so on; 5. Parents and children understand research program and volunteer to participant in the program, then sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Children or their families refused to participate in this research projects; 2. Children with a history of recent upper respiratory tract infection; 3. Children who are undergoing immunosuppressive therapy or gene therapy; 4. Severe heart failure,heart function III IV; 5. Other important organ dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plasma SDF-1 concentration;CXCR4mRNA;CXCR4mean fluorescence intensity;Chemotactic index; | — |
Countries
China
Contacts
Public ContactShouyong Wang
Outcome results
None listed