The correlation among different syndrome type of TCM and MRI imaging, histopathology, and molecular subtype in patients with femoral head necrosis

Status

Active, not recruiting

Phases

Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR-RPC-15006290

Enrollment

Unknown

Registered

2015-04-19

Start date

2015-06-30

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteonecrosis of the Femoral Head

Interventions

i stagnation and blood stasis group, deficiency :Nil

Eligibility

Sex/Gender

All

Age

30 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Patients who have been diagnosed with femoral head necrosis; 2.Age ranges from 30 to 80, regardless of gender; 3.Patients who have MRI of both hips done in our hospital; 4.Patients who need total hip replacement and who have been ruled out contraindication for surgery by pre-operation examination; 5.Patients who agree and sign the consent agreement.

Exclusion criteria

Exclusion criteria: 1.Ineligibility criteria; 2.History of previous hip surgery; 3.Severe congenital hip deformity; 4.Patients who were diagnosed with rheumatoid arthritis, ankylosing spondylitis, joint tuberculosis, pyogenic arthritis; 5.Patients who have other reasons believed to be unsuitable for the clinical study.

Design outcomes

Primary

Measure	Time frame
MRI imaging of hip;Serum bone turnover levels;LRP5,Beta-Catenin, OPG, TGF-beta1, VEGF, Ang-1;RANKL, IFN-alpha, IFN-beta, IL-6, IL-17;PPAR-gama, SREBP-2, PON-1, Adiponeetin, Leptin, visfatin, Omentin;Gross specimen analysis in necrotic femoral head;The epidemiological questionnaire of TCM syndrome in clinical patients with femoral haed necrosis;	—

Countries

China

Contacts

Public ContactWei He

hewei1123@21cn.com+86 13802516062

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026