stable coronary artery disease
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Healthy human: (1) Aged 35 to 79 years; (2) BMI 19 to 24[BMI=weight(kg)/height2(m2)]; (3) Without heart, liver, lung, kidney and other important organ diseases,without digestive system, respiratory system, circulatory system, blood system, endocrine system, nervous system and mental disorders; (4) No positive signs of clinical significance by physical examination; (5) Submitted informed consent. 2. Patients with stable coronary heart disease: (1) Aged 35 to 79 years; (2) Compliance with diagnostic criteria of stable coronary heart disease; (3) Classification of CCS cardiac function beween I-III; (4) Submitted informed consent.
Exclusion criteria
Exclusion criteria: 1. Healthy human: (1) Unable to exercise due to limb disorders or other reasons; (2) Women in pregnancy or lactation; (3) Other situations that researchers considered not suitable for the trial. 2. Patients with stable coronary heart disease: (1) Left main coronary artery stenosis; (2) Uncontrolled hypertension or systolic pressure=160mmHg and/or diastolic pressure=100mmHg after taken medicine; (3) Uncontrolled rapid arrhythmias with symptoms or hemodynamic disorders; (4) High or complete atrioventricular block; (5) acute endocarditis; (6) Obstructive hypertrophic cardiomyopathy; (7) Symptomatic severe aortic stenosis, decompensated heart failure, acute pulmonary embolism, deep vein thrombosis, acute pericarditis, myocarditis and acute aortic dissection; (8) Chronic pulmonary disease with dyspnea; (9) Stroke or transient ischemic attack with cognitive impairment in the short term; (10) The clinical problems that have not been corrected, such as infection, severe anemia, electrolyte disorder, hyperthyroidism, etc; (11) The abnormal function of liver and kidney (serum alanine aminotransferase or creatinine > 2 times the upper limit of normal reference value); (12) Unable to exercise due to limb disorders or other reasons; (13) Women in pregnancy or lactation; (14) Other situations that researchers considered not suitable for the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| metabolic equivalent; | — |
Secondary
| Measure | Time frame |
|---|---|
| oxygen uptake (VO2);VO2/kg;VO2/HR;carbon dioxide output(VCO2);minute ventilation(VE);VCO2/VO2;tidal volume(VT);respiration frequency(Rf);VE/VCO2;VE/VO2;the end-tidal CO2 pressures(PetCO2);st-segment deviation;heart rate recovery in 1min (HRR1);Borg Scale; | — |
Countries
China
Contacts
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine