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A birth cohort study on the effects of prenatal PM2.5 exposure on the health of offsprings

A birth cohort study on the associations of vehicle sourced PM2.5 chemical components with preterm birth and the mechanisms related to LINE-1 methylation in Guangzhou

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-ROC-17013496
Enrollment
Unknown
Registered
2017-11-23
Start date
2016-01-01
Completion date
Unknown
Last updated
2017-11-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm birth

Interventions

Low exposure group:Exposure to low PM2.5 concentrations
Relatively low exposure group:Exposure to relatively low PM2.5 concentrations
Relatively high exposure group:Exposure to relatively high PM2.5 concentrations
High exposure group:Exposure to high PM2.5 concentrations

Sponsors

Guangdong Provincial Institute of Public Health
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Maternal gestational weeks are less than 13 weeks; 2. The local residents who have regular antenatal cares in the same hospital; 3. Maternal aged =18 years.

Exclusion criteria

Exclusion criteria: 1. The mothers who have one of the following diseases: diabetes, hypertension, hyperthyroidism, chronic kidney disease, tuberculosis, heart disease and mental illness. 2. Refused to participate; 3. Pregnant women who have communication barriers; 4. Those we did obtain their consent.

Design outcomes

Primary

MeasureTime frame
RR;OR;PM2.5 exposure concentrations;Preterm birth rate;LINE-1 DNA methylation;PM2.5 constitutes;Activity model;—

Secondary

MeasureTime frame
Smoking;Drinking;Dietary pattern;Adverse pregnant events;—

Countries

China

Contacts

Public ContactTao Liu

Guangdong Provincial Institute of Public Health

gztt_2002@163.com+86 18927588462

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026