Major Depressive Disorder
Conditions
Interventions
Patients with mild to moderate depression:None
Patients with severe depression:None
Health control:None
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with depressive disorder need to meet all criteria as following: 1. Outpatients or inpatients, aged at least 18 years and not more than 65 years, Male or female; 2. Has a diagnosis of major depressive disorder by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria (confirmed by MINI), without psychotic symptoms; 3. Systemic anti-depressants treatment were not adopted during current episode, or has taken no anti-depressants in last 14 days; 4. Total score of HAMD-17 = 14 at screening; 5. Has at least primary school education and can understand the scales; 6. Signed an informed consent form by patients. Health control need to meet all criteria as follow: 1. Aged 18 to 65 years Male or female; 2. Meet no diagnosis in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria (confirmed by MINI); 3. Has at least primary school education and can understand the scales; 4. Signed an informed consent form by patients. ;Inclusion criteria: Patients with depressive disorder need to meet all criteria as following: 1. Outpatients or inpatients, aged at least 18 years and not more than 65 years, Male or female; 2. Has a diagnosis of major depressive disorder by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria (confirmed by MINI), without psychotic symptoms; 3. Systemic anti-depressants treatment were not adopted during current episode, or has taken no anti-depressants in last 14 days; 4. Total score of HAMD-17 = 14 at screening; 5. Has at least primary school education and can understand the scales; 6. Signed an informed consent form by patients. Health control need to meet all criteria as follow: 1. Aged 18 to 65 years Male or female; 2. Meet no diagnosis in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria (confirmed by MINI); 3. Has at least primary school education and can understand the scales; 4. Signed an informed consent form by patients. ;Inclusion criteria: Patients with depressive disorder need to meet all criteria as following: 1. Outpatients or inpatients, aged at least 18 years and not more than 65 years, Male or female; 2. Has a diagnosis of major depressive disorder by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria (confirmed by MINI), without psychotic symptoms; 3. Systemic anti-depressants treatment were not adopted during current episode, or has taken no anti-depressants in last 14 days; 4. Total score of HAMD-17 = 14 at screening; 5. Has at least primary school education and can understand the scales; 6. Signed an informed consent form by patients. Health control need to meet all criteria as follow: 1. Aged 18 to 65 years Male or female; 2. Meet no diagnosis in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria (confirmed by MINI); 3. Has at least primary school education and can understand the scales; 4. Signed an informed consent form by patients. ;Inclusion criteria: Patients with depressive disorder need to meet all criteria as following: 1. Outpatients or inpatients, aged at least 18 years and not more than 65 years, Male or female; 2. Has a diagnosis of major depressive disorder by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria (confirmed by MINI), without psychotic symptoms; 3. Systemic anti-depressants treatment were not adopted during current episode, or has taken no anti-depressants in last 14 days; 4. Total score of HAMD-17 = 14 at screening; 5. Has at least primary school education and can understand the scales; 6. Signed an informed consent form by patients. Health control need to meet all criteria as follow: 1. Aged 18 to 65 years Male or female; 2. Meet no diagnosis in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria (confirmed by MINI); 3. Has at least primary school education and can understand the scales; 4. Signed an informed consent form by patients. ;Inclusion criteria: Patients with depressive disorder need to meet all criteria as following: 1. Outpatients or inpatients, aged at least 18 years and not more than 65 years, Male or female; 2. Has a diagnosis of major depressive disorder by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria (confirmed by MINI), without psychotic symptoms; 3. Systemic anti-depressants treatment were not adopted during current episode, or has taken no anti-depressants in last 14 days; 4. Total score of HAMD-17 = 14 at screening; 5. Has at least primary school education and can understand the scales; 6. Signed an informed consent form by patients. Health control need to meet all criteria as follow: 1. Aged 18 to 65 years Male or female; 2. Meet no diagnosis in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria (confirmed by MINI); 3. Has at least primary school education and can understand the scales; 4. Signed an informed consent form by patients.
Exclusion criteria
Exclusion criteria: Patients meet any one of follow criteria should be excluded: 1. History of manic episode hypomania episode; 2. History of bipolar, schizophrenia, schizoaffective disorder, or other psychotic disorders; 3. History of drug and alcohol dependence or acute intoxication; 4. Women in pregnancy or lactation; 5. Has specific anxiety symptoms, total score of HAMA>14; 6. Significant risk of suicidal behaviors, with severe suicidal risk in MINI, or HAMD-17 Item 3(suicide) score =3; 7. History of independent sleep disorder (e.g. obstructive sleep apnea, narcolepsy, bruxism, periodic limb movement disorder, restless legs syndrome and so on); 8. Organic brain diseases; 9. History of head trauma induced unconsciousness more than one hour; or obvious mental retardation; 10. Current diseases which affect heart or respiratory, such as acute exacerbation of chronic obstructive pulmonary disease, acute exacerbation of asthma, sinus tachycardia, sinus bradycardia, arrhythmia and so on; 11. Current clinically significant disease. Health control meet any one of follow criteria should be excluded: 1. History of any diagnosis in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria; 2. History of independent sleep disorder (e.g. obstructive sleep apnea, narcolepsy, bruxism, periodic limb movement disorder, restless legs syndrome and so on); 3. Current diseases which affect heart or respiratory, such as acute exacerbation of chronic obstructive pulmonary disease, acute exacerbation of asthma, sinus tachycardia, sinus bradycardia, arrhythmia and so on; 4. History of drug and alcohol dependence or acute intoxication; 5. Women in pregnancy or lactation; 6. Current clinically significant disease; 7. History of head trauma induced unconsciousness more than two minutes.;Exclusion criteria: Patients meet any one of follow criteria should be excluded: 1. History of manic episode hypomania episode; 2. History of bipolar, schizophrenia, schizoaffective disorder, or other psychotic disorders; 3. History of drug and alcohol dependence or acute intoxication; 4. Women in pregnancy or lactation; 5. Has specific anxiety symptoms, total score of HAMA>14; 6. Significant risk of suicidal behaviors, with severe suicidal risk in MINI, or HAMD-17 Item 3(suicide) score =3; 7. History of independent sleep disorder (e.g. obstructive sleep apnea, narcolepsy, bruxism, periodic limb movement disorder, restless legs syndrome and so on); 8. Organic brain diseases; 9. History of head trauma induced unconsciousness more than one hour; or obvious mental retardation; 10. Current diseases which affect heart or respiratory, such as acute exacerbation of chronic obstructive pulmonary disease, acute exacerbation of asthma, sinus tachycardia, sinus bradycardia, arrhythmia and so on; 11. Current clinically significant disease. Health control meet any one of follow criteria should be excluded: 1. History of any diagnosis in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria; 2. History of independent sleep disorder (e.g. obstructive sleep apnea, narcolepsy, bruxism, periodic limb movement disorder, restless legs syndrome and so on); 3. Current diseases which affect heart or respiratory, such as acute exacerbation of chronic obstructive pulmonary disease, acute exacerbation of asthma, sinus tachycardia, sinus bradycardia, arrhythmia and so on; 4. History of drug and alcohol dependence or acute intoxication; 5. Women in pregnancy or lactation; 6. Current clinically significant disease; 7. History of head trauma induced unconsciousness more than two minutes.;Exclusion criteria: Patients meet any one of follow criteria should be excluded: 1. History of manic episode hypomania episode; 2. History of bipolar, schizophrenia, schizoaffective disorder, or other psychotic disorders; 3. History of drug and alcohol dependence or acute intoxication; 4. Women in pregnancy or lactation; 5. Has specific anxiety symptoms, total score of HAMA>14; 6. Significant risk of suicidal behaviors, with severe suicidal risk in MINI, or HAMD-17 Item 3(suicide) score =3; 7. History of independent sleep disorder (e.g. obstructive sleep apnea, narcolepsy, bruxism, periodic limb movement disorder, restless legs syndrome and so on); 8. Organic brain diseases; 9. History of head trauma induced unconsciousness more than one hour; or obvious mental retardation; 10. Current diseases which affect heart or respiratory, such as acute exacerbation of chronic obstructive pulmonary disease, acute exacerbation of asthma, sinus tachycardia, sinus bradycardia, arrhythmia and so on; 11. Current clinically significant disease. Health control meet any one of follow criteria should be excluded: 1. History of any diagnosis in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria; 2. History of independent sleep disorder (e.g. obstructive sleep apnea, narcolepsy, bruxism, periodic limb movement disorder, restless legs syndrome and so on); 3. Current diseases which affect heart or respiratory, such as acute exacerbation of chronic obstructive pulmonary disease, acute exacerbation of asthma, sinus tachycardia, sinus bradycardia, arrhythmia and so on; 4. History of drug and alcohol dependence or acute intoxication; 5. Women in pregnancy or lactation; 6. Current clinically significant disease; 7. History of head trauma induced unconsciousness more than two minutes.;Exclusion criteria: Patients meet any one of follow criteria should be excluded: 1. History of manic episode hypomania episode; 2. History of bipolar, schizophrenia, schizoaffective disorder, or other psychotic disorders; 3. History of drug and alcohol dependence or acute intoxication; 4. Women in pregnancy or lactation; 5. Has specific anxiety symptoms, total score of HAMA>14; 6. Significant risk of suicidal behaviors, with severe suicidal risk in MINI, or HAMD-17 Item 3(suicide) score =3; 7. History of independent sleep disorder (e.g. obstructive sleep apnea, narcolepsy, bruxism, periodic limb movement disorder, restless legs syndrome and so on); 8. Organic brain diseases; 9. History of head trauma induced unconsciousness more than one hour; or obvious mental retardation; 10. Current diseases which affect heart or respiratory, such as acute exacerbation of chronic obstructive pulmonary disease, acute exacerbation of asthma, sinus tachycardia, sinus bradycardia, arrhythmia and so on; 11. Current clinically significant disease. Health control meet any one of follow criteria should be excluded: 1. History of any diagnosis in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria; 2. History of independent sleep disorder (e.g. obstructive sleep apnea, narcolepsy, bruxism, periodic limb movement disorder, restless legs syndrome and so on); 3. Current diseases which affect heart or respiratory, such as acute exacerbation of chronic obstructive pulmonary disease, acute exacerbation of asthma, sinus tachycardia, sinus bradycardia, arrhythmia and so on; 4. History of drug and alcohol dependence or acute intoxication; 5. Women in pregnancy or lactation; 6. Current clinically significant disease; 7. History of head trauma induced unconsciousness more than two minutes.;Exclusion criteria: Patients meet any one of follow criteria should be excluded: 1. History of manic episode hypomania episode; 2. History of bipolar, schizophrenia, schizoaffective disorder, or other psychotic disorders; 3. History of drug and alcohol dependence or acute intoxication; 4. Women in pregnancy or lactation; 5. Has specific anxiety symptoms, total score of HAMA>14; 6. Significant risk of suicidal behaviors, with severe suicidal risk in MINI, or HAMD-17 Item 3(suicide) score =3; 7. History of independent sleep disorder (e.g. obstructive sleep apnea, narcolepsy, bruxism, periodic limb movement disorder, restless legs syndrome and so on); 8. Organic brain diseases; 9. History of head trauma induced unconsciousness more than one hour; or obvious mental retardation; 10. Current diseases which affect heart or respiratory, such as acute exacerbation of chronic obstructive pulmonary disease, acute exacerbation of asthma, sinus tachycardia, sinus bradycardia, arrhythmia and so on; 11. Current clinically significant disease. Health control meet any one of follow criteria should be excluded: 1. History of any diagnosis in Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria; 2. History of independent sleep disorder (e.g. obstructive sleep apnea, narcolepsy, bruxism, periodic limb movement disorder, restless legs syndrome and so on); 3. Current diseases which affect heart or respiratory, such as acute exacerbation of chronic obstructive pulmonary disease, acute exacerbation of asthma, sinus tachycardia, sinus bradycardia, arrhythmia and so on; 4. History of drug and alcohol dependence or acute intoxication; 5. Women in pregnancy or lactation; 6. Current clinically significant disease; 7. History of head trauma induced unconsciousness more than two minutes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EEG parameters;ECG parameters;electrical skin activity parameters;pulse;blood oxygenation;body temperature;environmental temperature;electromyography (EMG);sleep parameters; | — |
Countries
China
Contacts
Public ContactGang Wang;Gang Wang;Gang Wang;Gang Wang;Gang Wang ;;;;
Beijing Anding Hospital, Capital Medical University;Beijing Anding Hospital, Capital Medical University;Beijing Anding Hospital, Capital Medical University;Beijing Anding Hospital, Capital Medical University;Beijing Anding Hospital, Capital Medical University
Outcome results
None listed