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A study on the effects and mechanisms of gut microbiota on the occurrence and development of gastrointestinal fistula after gastrointestinal surgery

A study on the effects and mechanisms of gut microbiota on the occurrence and development of gastrointestinal fistula after gastrointestinal surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-ROC-17013140
Enrollment
Unknown
Registered
2017-10-28
Start date
2017-12-01
Completion date
Unknown
Last updated
2017-11-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Digestive tract fistula

Interventions

Stomach cancer patients:Collect preoperative and postoperative defecation and take mucosal specimens
Colonrectal cancer patients:Collect preoperative and postoperative defecation and take mucosal specimens
Patients with returned stoma of gastrointestinal fistula:Collect preoperative and postoperative defecation and take mucosal specimens
Patients with gastrointestinal fistula after gastrointestinal surgery:Collect preoperative and postoperative defecation and drainage fluid from digestive tract fistula

Sponsors

Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, the Fourth Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Gastric cancer patients intend to receive surgery, radiotherapy, chemotherapy and other treatments; 2. Colorectal cancer patients intend to receive surgery, radiotherapy, chemotherapy and other treatments; 3. Patients with returned stoma of gastrointestinal tract fistula; 4. Patients with gastrointestinal fistula after gastrointestinal surgery; 5. Subjects who volunteer to the trial and sign informed consent.;Inclusion criteria: 1. Gastric cancer patients intend to receive surgery, radiotherapy, chemotherapy and other treatments; 2. Colorectal cancer patients intend to receive surgery, radiotherapy, chemotherapy and other treatments; 3. Patients with returned stoma of gastrointestinal tract fistula; 4. Patients with gastrointestinal fistula after gastrointestinal surgery; 5. Subjects who volunteer to the trial and sign informed consent.;Inclusion criteria: 1. Gastric cancer patients intend to receive surgery, radiotherapy, chemotherapy and other treatments; 2. Colorectal cancer patients intend to receive surgery, radiotherapy, chemotherapy and other treatments; 3. Patients with returned stoma of gastrointestinal tract fistula; 4. Patients with gastrointestinal fistula after gastrointestinal surgery; 5. Subjects who volunteer to the trial and sign informed consent.;Inclusion criteria: 1. Gastric cancer patients intend to receive surgery, radiotherapy, chemotherapy and other treatments; 2. Colorectal cancer patients intend to receive surgery, radiotherapy, chemotherapy and other treatments; 3. Patients with returned stoma of gastrointestinal tract fistula; 4. Patients with gastrointestinal fistula after gastrointestinal surgery; 5. Subjects who volunteer to the trial and sign informed consent.;Inclusion criteria: 1. Gastric cancer patients intend to receive surgery, radiotherapy, chemotherapy and other treatments; 2. Colorectal cancer patients intend to receive surgery, radiotherapy, chemotherapy and other treatments; 3. Patients with returned stoma of gastrointestinal tract fistula; 4. Patients with gastrointestinal fistula after gastrointestinal surgery; 5. Subjects who volunteer to the trial and sign informed consent.

Exclusion criteria

Exclusion criteria: Subjects with involuntary defecation or defecation inability.;Exclusion criteria: Subjects with involuntary defecation or defecation inability.;Exclusion criteria: Subjects with involuntary defecation or defecation inability.;Exclusion criteria: Subjects with involuntary defecation or defecation inability.;Exclusion criteria: Subjects with involuntary defecation or defecation inability.

Design outcomes

Primary

MeasureTime frame
diversity detection of gut microbiota (based on the second generation of high-throughput 16S sequencing technology);Sequencing of the genome of the gut microbiota;Intestinal mucosal function test;—

Countries

China

Contacts

Public ContactQingchuan Zhao;Qingchuan Zhao;Qingchuan Zhao;Qingchuan Zhao;Qingchuan Zhao ;;;;

Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, the Fourth Military Medical University;Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, the Fourth Military Medical University;Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, the Fourth Military Medical University;Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, the Fourth Military Medical University;Department of Digestive Surgery, Xijing Hospital of Dige

zhaoqc@fmmu.edu.cn;zhaoqc@fmmu.edu.cn;zhaoqc@fmmu.edu.cn;zhaoqc@fmmu.edu.cn;zhaoqc@fmmu.edu.cn+86 13809153899;+86 13809153899;+86 13809153899;+86 13809153899;+86 13809153899

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026