Epilepsy
Conditions
Interventions
Sponsors
Children's Hospital of Fudan University
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: Patients who have received at least 2 antiepileptic drugs therapy but continue to have seizures. Parents informed consent.;Inclusion criteria: Patients who have received at least 2 antiepileptic drugs therapy but continue to have seizures. Parents informed consent.;Inclusion criteria: Patients who have received at least 2 antiepileptic drugs therapy but continue to have seizures. Parents informed consent.;Inclusion criteria: Patients who have received at least 2 antiepileptic drugs therapy but continue to have seizures. Parents informed consent.;Inclusion criteria: Patients who have received at least 2 antiepileptic drugs therapy but continue to have seizures. Parents informed consent.
Exclusion criteria
Exclusion criteria: (1) Children with secondary epilepsy, including intracranial structural abnormalities, sequelae of central nervous system infection, hypoxic encephalopathy, metabolic encephalopathy and other causes of intractable epilepsy; (2) Patients with contraindication or special curative effect with ketogenic diet; (3) Children with chronic diseases of other organs, such as diabetes, obesity, autoimmune diseases, cancer, chronic kidney disease, liver dysfunction, chronic diarrhea or gastrointestinal dysfunction and so on; (4) Children who use probiotics or antibiotics within 2 weeks before stool sampling; (5) Patients with poor treatment compliance.;Exclusion criteria: (1) Children with secondary epilepsy, including intracranial structural abnormalities, sequelae of central nervous system infection, hypoxic encephalopathy, metabolic encephalopathy and other causes of intractable epilepsy; (2) Patients with contraindication or special curative effect with ketogenic diet; (3) Children with chronic diseases of other organs, such as diabetes, obesity, autoimmune diseases, cancer, chronic kidney disease, liver dysfunction, chronic diarrhea or gastrointestinal dysfunction and so on; (4) Children who use probiotics or antibiotics within 2 weeks before stool sampling; (5) Patients with poor treatment compliance.;Exclusion criteria: (1) Children with secondary epilepsy, including intracranial structural abnormalities, sequelae of central nervous system infection, hypoxic encephalopathy, metabolic encephalopathy and other causes of intractable epilepsy; (2) Patients with contraindication or special curative effect with ketogenic diet; (3) Children with chronic diseases of other organs, such as diabetes, obesity, autoimmune diseases, cancer, chronic kidney disease, liver dysfunction, chronic diarrhea or gastrointestinal dysfunction and so on; (4) Children who use probiotics or antibiotics within 2 weeks before stool sampling; (5) Patients with poor treatment compliance.;Exclusion criteria: (1) Children with secondary epilepsy, including intracranial structural abnormalities, sequelae of central nervous system infection, hypoxic encephalopathy, metabolic encephalopathy and other causes of intractable epilepsy; (2) Patients with contraindication or special curative effect with ketogenic diet; (3) Children with chronic diseases of other organs, such as diabetes, obesity, autoimmune diseases, cancer, chronic kidney disease, liver dysfunction, chronic diarrhea or gastrointestinal dysfunction and so on; (4) Children who use probiotics or antibiotics within 2 weeks before stool sampling; (5) Patients with poor treatment compliance.;Exclusion criteria: (1) Children with secondary epilepsy, including intracranial structural abnormalities, sequelae of central nervous system infection, hypoxic encephalopathy, metabolic encephalopathy and other causes of intractable epilepsy; (2) Patients with contraindication or special curative effect with ketogenic diet; (3) Children with chronic diseases of other organs, such as diabetes, obesity, autoimmune diseases, cancer, chronic kidney disease, liver dysfunction, chronic diarrhea or gastrointestinal dysfunction and so on; (4) Children who use probiotics or antibiotics within 2 weeks before stool sampling; (5) Patients with poor treatment compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| seizure frequency; | — |
Countries
China
Contacts
Public ContactYunjian Zhang;Yunjian Zhang;Yunjian Zhang;Yunjian Zhang;Yunjian Zhang ;;;;
Children's Hospital of Fudan University;Children's Hospital of Fudan University;Children's Hospital of Fudan University;Children's Hospital of Fudan University;Children's Hospital of Fudan University
Outcome results
None listed