Reflux Esophagitis
Conditions
Interventions
Reflux esophagitis:No
Control:No
Gastric and duodenal ulcer:No
Sponsors
Department of Gastroenterology, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Reflux esophagitis group: 1. Aged from 18 to 60 years old; 2. GERD related symptoms, oesophagogastroduodenoscopy shows reflux esophagitis without peptic ulcer; 3. No severe systemic diseases; 4. Besides the third molars, individuals bear 20 teeth at least. Gastric/duodenal ulcer group: 1. Aged from 18 to 60 years old; 2. Peptic ulcer related symptoms without GERD related symptoms, oesophagogastroduodenoscopy shows peptic ulcer without reflux esophagitis; 3. No severe systemic diseases; 4. Besides the third molars, individuals bear 20 teeth at least. Control group: 1. Aged from 18 to 60 years old; 2. No peptic ulcer related symptoms or GERD related symptoms, oesophagogastroduodenoscopy do not show peptic ulcer or reflux esophagitis; 3. No severe systemic diseases; 4. Besides the third molars, individuals bear 20 teeth at least.;Inclusion criteria: Reflux esophagitis group: 1. Aged from 18 to 60 years old; 2. GERD related symptoms, oesophagogastroduodenoscopy shows reflux esophagitis without peptic ulcer; 3. No severe systemic diseases; 4. Besides the third molars, individuals bear 20 teeth at least. Gastric/duodenal ulcer group: 1. Aged from 18 to 60 years old; 2. Peptic ulcer related symptoms without GERD related symptoms, oesophagogastroduodenoscopy shows peptic ulcer without reflux esophagitis; 3. No severe systemic diseases; 4. Besides the third molars, individuals bear 20 teeth at least. Control group: 1. Aged from 18 to 60 years old; 2. No peptic ulcer related symptoms or GERD related symptoms, oesophagogastroduodenoscopy do not show peptic ulcer or reflux esophagitis; 3. No severe systemic diseases; 4. Besides the third molars, individuals bear 20 teeth at least.;Inclusion criteria: Reflux esophagitis group: 1. Aged from 18 to 60 years old; 2. GERD related symptoms, oesophagogastroduodenoscopy shows reflux esophagitis without peptic ulcer; 3. No severe systemic diseases; 4. Besides the third molars, individuals bear 20 teeth at least. Gastric/duodenal ulcer group: 1. Aged from 18 to 60 years old; 2. Peptic ulcer related symptoms without GERD related symptoms, oesophagogastroduodenoscopy shows peptic ulcer without reflux esophagitis; 3. No severe systemic diseases; 4. Besides the third molars, individuals bear 20 teeth at least. Control group: 1. Aged from 18 to 60 years old; 2. No peptic ulcer related symptoms or GERD related symptoms, oesophagogastroduodenoscopy do not show peptic ulcer or reflux esophagitis; 3. No severe systemic diseases; 4. Besides the third molars, individuals bear 20 teeth at least.;Inclusion criteria: Reflux esophagitis group: 1. Aged from 18 to 60 years old; 2. GERD related symptoms, oesophagogastroduodenoscopy shows reflux esophagitis without peptic ulcer; 3. No severe systemic diseases; 4. Besides the third molars, individuals bear 20 teeth at least. Gastric/duodenal ulcer group: 1. Aged from 18 to 60 years old; 2. Peptic ulcer related symptoms without GERD related symptoms, oesophagogastroduodenoscopy shows peptic ulcer without reflux esophagitis; 3. No severe systemic diseases; 4. Besides the third molars, individuals bear 20 teeth at least. Control group: 1. Aged from 18 to 60 years old; 2. No peptic ulcer related symptoms or GERD related symptoms, oesophagogastroduodenoscopy do not show peptic ulcer or reflux esophagitis; 3. No severe systemic diseases; 4. Besides the third molars, individuals bear 20 teeth at least.;Inclusion criteria: Reflux esophagitis group: 1. Aged from 18 to 60 years old; 2. GERD related symptoms, oesophagogastroduodenoscopy shows reflux esophagitis without peptic ulcer; 3. No severe systemic diseases; 4. Besides the third molars, individuals bear 20 teeth at least. Gastric/duodenal ulcer group: 1. Aged from 18 to 60 years old; 2. Peptic ulcer related symptoms without GERD related symptoms, oesophagogastroduodenoscopy shows peptic ulcer without reflux esophagitis; 3. No severe systemic diseases; 4. Besides the third molars, individuals bear 20 teeth at least. Control group: 1. Aged from 18 to 60 years old; 2. No peptic ulcer related symptoms or GERD related symptoms, oesophagogastroduodenoscopy do not show peptic ulcer or reflux esophagitis; 3. No severe systemic diseases; 4. Besides the third molars, individuals bear 20 teeth at least.
Exclusion criteria
Exclusion criteria: (1) Confirmed or suspected malignant tumors; (2) Pregnant and breeding women; (3) Alcoholism or cigarrett taking; (4) Anorexia nervosa, neurological vomiting; (5) Esophageal stricture; (6) Long-term teeth grinding; (7) Long-term acidic environment for teeth; (8) taking medicine that affect the secretion of saliva; (9) taking antibiotics and antacids; (10) Tetracycline pigmentation teeth, dental fluorosis and ongoing orthodontic treatment; (11) Suffering from diseases that affect saliva secretion, such as xerostomia syndrome, sialolithiasis, salivary gland inflammation or maxillofacial tumors; (12) Risk factors of dental caries; (13) Other conditions determined by researchers to be not suitable for enrollment.;Exclusion criteria: (1) Confirmed or suspected malignant tumors; (2) Pregnant and breeding women; (3) Alcoholism or cigarrett taking; (4) Anorexia nervosa, neurological vomiting; (5) Esophageal stricture; (6) Long-term teeth grinding; (7) Long-term acidic environment for teeth; (8) taking medicine that affect the secretion of saliva; (9) taking antibiotics and antacids; (10) Tetracycline pigmentation teeth, dental fluorosis and ongoing orthodontic treatment; (11) Suffering from diseases that affect saliva secretion, such as xerostomia syndrome, sialolithiasis, salivary gland inflammation or maxillofacial tumors; (12) Risk factors of dental caries; (13) Other conditions determined by researchers to be not suitable for enrollment.;Exclusion criteria: (1) Confirmed or suspected malignant tumors; (2) Pregnant and breeding women; (3) Alcoholism or cigarrett taking; (4) Anorexia nervosa, neurological vomiting; (5) Esophageal stricture; (6) Long-term teeth grinding; (7) Long-term acidic environment for teeth; (8) taking medicine that affect the secretion of saliva; (9) taking antibiotics and antacids; (10) Tetracycline pigmentation teeth, dental fluorosis and ongoing orthodontic treatment; (11) Suffering from diseases that affect saliva secretion, such as xerostomia syndrome, sialolithiasis, salivary gland inflammation or maxillofacial tumors; (12) Risk factors of dental caries; (13) Other conditions determined by researchers to be not suitable for enrollment.;Exclusion criteria: (1) Confirmed or suspected malignant tumors; (2) Pregnant and breeding women; (3) Alcoholism or cigarrett taking; (4) Anorexia nervosa, neurological vomiting; (5) Esophageal stricture; (6) Long-term teeth grinding; (7) Long-term acidic environment for teeth; (8) taking medicine that affect the secretion of saliva; (9) taking antibiotics and antacids; (10) Tetracycline pigmentation teeth, dental fluorosis and ongoing orthodontic treatment; (11) Suffering from diseases that affect saliva secretion, such as xerostomia syndrome, sialolithiasis, salivary gland inflammation or maxillofacial tumors; (12) Risk factors of dental caries; (13) Other conditions determined by researchers to be not suitable for enrollment.;Exclusion criteria: (1) Confirmed or suspected malignant tumors; (2) Pregnant and breeding women; (3) Alcoholism or cigarrett taking; (4) Anorexia nervosa, neurological vomiting; (5) Esophageal stricture; (6) Long-term teeth grinding; (7) Long-term acidic environment for teeth; (8) taking medicine that affect the secretion of saliva; (9) taking antibiotics and antacids; (10) Tetracycline pigmentation teeth, dental fluorosis and ongoing orthodontic treatment; (11) Suffering from diseases that affect saliva secretion, such as xerostomia syndrome, sialolithiasis, salivary gland inflammation or maxillofacial tumors; (12) Risk factors of dental caries; (13) Other conditions determined by researchers to be not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Calcium in the saliva;Inorganic phosphorus in saliva;Secretory immunoglobulin A in saliva;Mucin 5B in saliva;Mucin 7 in saliva;HTN 1 in saliva;Fluoride in saliva, etc; | — |
Countries
China
Contacts
Public ContactHuan Tong, Hao Wu;Huan Tong, Hao Wu;Huan Tong, Hao Wu;Huan Tong, Hao Wu;Huan Tong, Hao Wu ;;;;
Department of Gastroenterology, West China Hospital, Sichuan University;Department of Gastroenterology, West China Hospital, Sichuan University;Department of Gastroenterology, West China Hospital, Sichuan University;Department of Gastroenterology, West China Hospital, Sichuan University;Department of Gastroenterology, West China Hospital, Sichuan University
Outcome results
None listed