knee osteoarthritis
Conditions
Interventions
osteoarthritic group:none
control group:none
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meet the knee osteoarthritis diagnostic standard of Primary OA of the American Rheumatism Association criteria; 2. OA Patients with Kellgren-Lawrence grade IV; 3. Undergoing total knee arthroplasty;Inclusion criteria: 1. Meet the knee osteoarthritis diagnostic standard of Primary OA of the American Rheumatism Association criteria; 2. OA Patients with Kellgren-Lawrence grade IV; 3. Undergoing total knee arthroplasty;Inclusion criteria: 1. Meet the knee osteoarthritis diagnostic standard of Primary OA of the American Rheumatism Association criteria; 2. OA Patients with Kellgren-Lawrence grade IV; 3. Undergoing total knee arthroplasty;Inclusion criteria: 1. Meet the knee osteoarthritis diagnostic standard of Primary OA of the American Rheumatism Association criteria; 2. OA Patients with Kellgren-Lawrence grade IV; 3. Undergoing total knee arthroplasty;Inclusion criteria: 1. Meet the knee osteoarthritis diagnostic standard of Primary OA of the American Rheumatism Association criteria; 2. OA Patients with Kellgren-Lawrence grade IV; 3. Undergoing total knee arthroplasty
Exclusion criteria
Exclusion criteria: 1. Past history of joint puncture with drug injection; 2. Secondary OA caused by trauma, infection, immune disease, genetic disease or other definite factors; 3. Synovial fluid contaminated with blood.;Exclusion criteria: 1. Past history of joint puncture with drug injection; 2. Secondary OA caused by trauma, infection, immune disease, genetic disease or other definite factors; 3. Synovial fluid contaminated with blood.;Exclusion criteria: 1. Past history of joint puncture with drug injection; 2. Secondary OA caused by trauma, infection, immune disease, genetic disease or other definite factors; 3. Synovial fluid contaminated with blood.;Exclusion criteria: 1. Past history of joint puncture with drug injection; 2. Secondary OA caused by trauma, infection, immune disease, genetic disease or other definite factors; 3. Synovial fluid contaminated with blood.;Exclusion criteria: 1. Past history of joint puncture with drug injection; 2. Secondary OA caused by trauma, infection, immune disease, genetic disease or other definite factors; 3. Synovial fluid contaminated with blood.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma Selenium, Copper, Zinc, Iron, Manganese and Cadmium concentrations;Synovial fluid Selenium, Copper, Zinc, Iron, Manganese and Cadmium concentrations;Synovial membrane Selenium, Copper, Zinc, Iron, Manganese and Cadmium concentrations;Cartilage Selenium, Copper, Zinc, Iron, Manganese and Cadmium concentrations;Zip8 mRNA and protein level of cartilage and synovial membrane; | — |
Secondary
| Measure | Time frame |
|---|---|
| MMP3/6/9/13 mRNA and protein level of cartilage and synovial membrane;Selenoproteome level of cartilage and synovial membrane.; | — |
Countries
China
Contacts
Public ContactPengde Kang;Pengde Kang;Pengde Kang;Pengde Kang;Pengde Kang ;;;;
West China Hospital of Sichuan Unniversity;West China Hospital of Sichuan Unniversity;West China Hospital of Sichuan Unniversity;West China Hospital of Sichuan Unniversity;West China Hospital of Sichuan Unniversity
Outcome results
None listed