schizophrenia, depression, bipolar disorder
Conditions
Interventions
schizophrenia group:without
depression group:without
bipolar disorder group:without
Sponsors
The department of psychiatry, Xijing Hospital
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: Schizophrenia group: 1. Subject to consent by Drug Clinical Trials Ethics Committee of the First Affiliated Hospital, Fourth Military Medical University. The guardian of all participants need to sign a written informed consent; 2. 100 patients with schizophrenia or schizophrenia-like disorder who meet the DSM-5 diagnostic criteria will be recruited from outpatients or inpatients at the First Affiliated Hospital of Fourth Military Medical University; the score of Positive and negative symptoms scale (PANSS) is greater than or equal to 60; Aged 16 to 65; 3. Did not use probiotics and probiotic fermented food within 1 mouth; 4. Did not use any antibiotics within 1 month. Depression group: 1. Subject to consent by Drug Clinical Trials Ethics Committee of the First Affiliated Hospital, Fourth Military Medical University. All participants (or guardians) need to sign a written informed consent; 2. 100 patients with major depressive disorder who meet the DSM-5 diagnostic criteria will be recruited from outpatients or inpatients at the First Affiliated Hospital of Fourth Military Medical University; the score of HAMD is greater than or equal to 18; Aged 16 to 65 years; 3. Did not use probiotics and probiotic fermented food within 1 mouth; 4. Did not use any antibiotics within 1 month. Bipolar disorder group: 1. Subject to consent by Drug Clinical Trials Ethics Committee of the First Affiliated Hospital, Fourth Military Medical University. All participants (or guardians) need to sign a written informed consent; 2. 100 patients (50 cases of depressive episodes, 50 cases of hypomania or manic episodes) with bipolar disorder who meet the DSM-5 diagnostic criteria will be recruited from outpatients or inpatients at the First Affiliated Hospital of Fourth Military Medical University; HAMD score >= 18 points or YMRS score >= 20 points; Aged 16 to 65 years; 3. Did not use probiotics and probiotic fermented food within 1 mouth; 4. Did not use any antibiotics within 1 month. Control group: 1. Subject to consent by Drug Clinical Trials Ethics Committee of the First Affiliated Hospital, Fourth Military Medical University. All participants (or guardians) need to sign a written informed consent; 2. 100 subjects aged 16 to 65 years old will be recruited from physical examination center of the First Affiliated Hospital, Fourth Military Medical University; 3. Did not use probiotics and probiotic fermented food within 1 mouth; 4. Did not use any antibiotics within 1 month.
Exclusion criteria
Exclusion criteria: 1. Patients with inflammatory bowel disease, crohn's disease or other diseases of the digestive system, patients with other organic diseases; 2. Obesity: BMI >= 28.0; hyperglycemia: FPG >= 6.1mmol/L and/or somebody has been diagnosed with diabetes and treatment; TG >= 2.3 mmol/L; hypertension: systolic >= 140mmHg or diastolic blood pressure >= 90mmHg; 3. Pregnant or lactating women; 4. Severely unbalanced diet, such as high-fat diet or long-term vegetarians; 5. Suffering from other mental disorders in line with DSM-5 diagnostic criteria; 6. Taken any kind of psychotropic drugs or antipyretic analgesics in sufficient doses for more than 2 days in the nearly two weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal Sample Test;Hamilton depression scale;Young manic rating scale;positive and negative syndrome scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Global Assessment Function; | — |
Countries
China
Contacts
Public ContactHuaning Wang
Department of psychiatry, Xijing Hospital
Outcome results
None listed