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The change of the brain structure and function using preoperative fMRI examination in the nicotine abstinence: a Clinical Cohort Study

Study on the neural mechanism of nicotine withdrawal induced increased pain sensitivity

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-ROC-17011004
Enrollment
Unknown
Registered
2017-03-28
Start date
2017-04-04
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain

Interventions

non-smokers:no
smokers:no

Sponsors

Eastern Hepatobiliary Hospital
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
30 Years to 70 Years

Inclusion criteria

Inclusion criteria: Male, 30-70 years old, Han nationality, right-handed, BMI between 18-26, no other substance addiction, no neurological and mental diseases, no brain lesions and brain trauma history, no sleep dysfunction and long time with taking sedative drugs, no chronic pain and long period of taking pain medication history, liver Child grade A, bilirubin <34.2umol/L, no serious organ decompensated disease

Exclusion criteria

Exclusion criteria: 1. not suitable for patients with magnetic resonance imaging; 2. the researchers believe that other reasons are not suitable for clinical trials.

Design outcomes

Primary

MeasureTime frame
fMRI;—

Secondary

MeasureTime frame
BDI;STAI;PSQ;Fagerstrom;MNWS;QSU-Brief;Plasma nicotine content;Plasma cotinine content;Urine nicotine content;Urine cotinine content;—

Countries

China

Contacts

Public ContactZhijie Lu

Department of Anesthesiology, Eastern Hepatobiliary Hospital, Second Military Medical University

lzjwxyz@163.com+86 13501621611

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026