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Study on the structure and function of the intestinal microbial community in patients with hepatitis B cirrhosis and ascites by meta-omics approaches

Study on the structure and function of the intestinal microbial community in patients with hepatitis B cirrhosis and ascites by meta-omics approaches

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-ROC-16009630
Enrollment
Unknown
Registered
2016-10-26
Start date
2017-01-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatitis B Cirrhosis

Interventions

three group:none

Sponsors

Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) there was a history of hepatitis B or HBsAg positive for more than 6 months; (2) diagnosis of liver cirrhosis; (3) aged 18 ~ 65 years old; (4) no use of antibiotics and intestinal flora in the near 4w; (5) the patients or their guardians agreed to participate in a randomized controlled trial and signed the informed consent form.

Exclusion criteria

Exclusion criteria: (1) with liver cancer; (2) acute and chronic hepatitis not caused by HBV infection; (3) with diabetes mellitus; (4) Suffering from severe underlying diseases, including chronic respiratory failure, circulatory failure, renal failure and so on; (5) Orthotopic organ transplantation (such as liver, kidney, lung, heart) or bone marrow transplantation and stem cell transplantation; (7)Immune deficiency patients, such as HIV infection; (8) the use of antibiotics and intestinal flora in the near 4w; (9) the researchers think that the other situation is not suitable for the group

Design outcomes

Primary

MeasureTime frame
Intestinal flora metagenomics, metatranscriptomics, metaproteomics;

Countries

China

Contacts

Public ContactYongping Mu

Institute of Liver Diseases, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine

ypmu8888@126.com+86 13818869248

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026