acute respiratory distress syndrome
Conditions
Interventions
Case series:Prone positioning ventilation
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. aged 18 years or more; 2. diagnosis of severe ARDS: (1) Within 1 week of a known clinical insult or new or worsening respiratory symptoms; (2) Bilateral opacitiesnot fully explained by effusions, lobar/lung collapse, or nodules; (3) Respiratory failure not fully explained by cardiac failure or fluid overload Need objective assessment (eg, echocardiography) to exclude hydrostatic edema if no risk factor present; (4) PaO2/FiO2=150mmHg,PPEP=5cmH2O.
Exclusion criteria
Exclusion criteria: 1. Hemodynamic instability: Cardiac pacemaker inserted in the last 2 days or life-threatening arrhythmias or circulatory disorders (use of large doses of vasoactive drugs); 2. Intracranial pressure >30 mm Hg or cerebral perfusion pressure <60 mmHg; 3. Massive hemoptysis requiring an immediate surgical or interventional radiology procedure; 4. Tracheal surgery or sternotomy during the previous 15 days; 5. Serious facial trauma or facial surgery; 6. Deep venous thrombosis treated for less than 2 days; 7. Anterior chest wall placed closed thoracic drainage device; 8. Open wound of abdominal cavity; 9. Unstable spine; 10. femur or pelvic fractures; 11. Pregnant women; 12. Use of extracorporeal membrane oxygenation (ECMO) before inclusion; 13. Chronic respiratory failure requiring oxygen therapy or non-invasive ventilation(NIV); 14. Previous inclusion in the present study; 15. Opposition from next of kin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PaO2;PaCO2; | — |
Countries
China
Contacts
Public ContactTingting Liu
West China Hospital, Sichuan University
Outcome results
None listed