Mild Cognitive Impairment (MCI)
Conditions
Interventions
MCI combined intervention group :Folic acid, 0.8mg /day, Vitamin B12 25µg /day, oral, eighteen months
MCI folic acid intervention group :folic acid, 0.8mg /day, oral, eighteen months
MCI vitamin B12 intervention group :vitamin B12 25µg/day, oral, eighteen months
vitamin C control group:Vitamin C 100mg/day
Sponsors
Tianjin Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Community-based elderly subjects aged more than 65 years old; 2. Memory complaints reported by the patient, family, or physician, of at least a 6-month duration and preferably corroborated by an informant; 3. Mild quantitative impairments in cognitive function were assessed by the Chinese version of the 30-point Mini Mental State Examination (MMSE) using age- and education-based norms (cutoff point was set at 1.5 SD below the mean age- and education-adjusted MMSE scores); 4. Decreased daily living ability and social function, as measured by the daily living scale, score is below 18. 5. Absence of dementia (according to DSM-IV criteria), psychiatric disorder, cerebral damage, or any active neuropsychiatric condition producing disability; Subjects conforming to five items above can be determined as MCI and included in our study.
Exclusion criteria
Exclusion criteria: 1. Neurological examination found the sign of local central nerve obstruction such as obvious paralysisunilateral sensory disturbance and aphasia etc, history of cerebrovascular diseases (hemorrhagic and ischemic stroke), brain injury or bone fracture; 2. Medical diseases such as asthmatic bronchitissevere hypertensionangina pectoris and severe infection; 3. Psychotic patients with evident anxiety and depressed emotion and subjects with endocrine system history of disease(hyperthyroidism,thyroid hypofunction, systemic lupus eythematosus, rheumatoid arthritis); 4. Newly discovered or advanced tumor; 5. Surgery or diseases of the stomach or small intestine; 6. Visual perception,auditory perceptual disorders or languages communication difficulties,all of which may influence measurement of cognitive function; 7. Alcohol dependence and other psychoactive substance abuse such as antipsychotic drug,benzodiazepines or taking medicine influencing cognitive function; 8. Who have implanted metallic devices such as pacemakers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum folate;serum vitaminB12;Wdchsler Intelligence Scale(Chinese version); | — |
Secondary
| Measure | Time frame |
|---|---|
| tumor necrosis factor;Interleukin 6 (IL-6);plasma Aß40;S-adenosylmethionine;plasma homocysteine;S-adenosylhomocysteine; | — |
Countries
China
Contacts
Public ContactGuowei Huang
Tianjin Medical University
Outcome results
None listed