bronchial asthma
Conditions
Interventions
steroid-sensitive asthma:oral glucocorticoid treatment
steroid-insensitive asthma:oral glucocorticoid treatment
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
19 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed as asthma based on clinical symptoms and positive results of bronchial provocation or dilation tests according to the Global Initiative for Asthma (GINA) Guidelines; 2. Male or female aged 18 to 65 years with active asthma ,wheezing,shortness of breath, chest tightness or coughing, taking oral glucocorticoid treatment; 3. Agreed to join the study and signed a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Presence of active lung diseases other than asthma (chronic obstructive pulmonarydisease, respiratorytract infections,bronchiectasis,etc); 2. Current and ex-smokers with more than 5 pack-years of smoking history; 3. Recently (within 4 weeks) treatment with systemic or inhaled corticosteroids; 4. Allergic to inhaled corticosteroids or beta 2 agonists; 5. Serious conditions such as heart, liver, kidneys, lungs, gastrointestinal tract, endocrine or blood system diseases. History of alcoholism and drug abuse; 6. Currently or recently participation in another clinical study; 7. Other reasons that the researchers believed inappropriate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| neutrophil apoptosis rate;improvement in FEV1 after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| concentrations of inflammatory cytokines; | — |
Countries
China
Contacts
Public ContactJungang Xie
Outcome results
None listed