different stages of chronic liver disease
Conditions
Interventions
Normal group:none
NAFL group :none
Virus hepatitis group:none
Liver fibrosis (S1-2) group:none
Liver fibrosis (S3) group:none
Compensated cirrhosis group:none
Sponsors
Southern Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Male of female, aged from 20 to 60; 2. normal group: no alcohol dependence medical history, equivalent amount of ethanol 80g/d), no drinking in nearly 2 weeks, no significant liver dysfunction or severe diseases; 3. case group: meeting the diagnostic criteria of the research program; 4. subjects must sign informed consent.
Exclusion criteria
Exclusion criteria: 1. subjects have been participate in other clinical studies or infected before this study within 4 weeks; 2. subjects take part in other studies during this study; 3. gravida or lactating female; 4. subjects with history of hypoglycemic syncope,blood phobia 5. subjects with severe complications of liver diseases, such as spontaneous bacterial peritonitis, hepatic encephalopathy, hepatorenal syndrome, hepatomyocardosis, hepatopulmonary syndrome, hepatic failure andthe like; 6. subjects with other severe systemic diseases, such as AIDS, cephalomeningitis, myocardial infarct, renal failure, hemorrhage of digestive tract andthe like; 7. subjects with neurological or psychiatric diseases, such as paralysis agitans andmajor depressive disorder; researchers exclude subjects from this study because of other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| caveolin-1;receptor for advanced glycation end products, RAGE;high mobility group box-1 protein, HMGB-1;advanced glycationend products, AGEs; | — |
Countries
China
Contacts
Public ContactLYU Zhiping
Outcome results
None listed