epilepsy
Conditions
Interventions
drug resistant and responsive patients:anti-epileptic durgs
Sponsors
Institute of Clinical Pharmacology, Central South University Xiangya School of Medicine
Eligibility
Sex/Gender
Male
Age
No minimum to 80 Years
Inclusion criteria
Inclusion criteria: The epilepsy patient blood specimens collected inclusion criteria: (1) diagnostic classification standards of the 1981 International League Against Epilepsy seizures and 1989 seizures and epilepsy syndrome classification criteria; (2) by CT or magnetic resonance imaging (MRI), EEG, intracranial lesions, vascular malformation and other lesions not found; (3) the blood, liver and kidney function tests abnormal; (4) after diagnosis, voluntarily participate in the trial and collaborators signed informed consent; (5) The application of carbamazepine, valproic acid satisfied and O'Casey equality antiepileptic drugs regular treatment, seamless service, reaches a steady state plasma concentration; (6) maintenance dose treatment: from the application of drug therapy to enrolled patients, twice in a row or more follow-up, clinician judgment, that the curative effect, no need to adjust the medication; Brain tissue of patients with epilepsy surgery inclusion criteria: (1) epilepsy surgery patients, idiopathic epilepsy, surgical resection of lesions, diagnostic classification standards of the 1981 International League Against Epilepsy seizures and 1989 seizures and epilepsy syndrome classification criteria; (2) the blood, liver and kidney function tests abnormal; (3) after diagnosis, voluntarily participate in the trial and collaborators signed informed consent.
Exclusion criteria
Exclusion criteria: The epilepsy patient blood specimens collected inclusion criteria: (1) serious organic disease such as cancer, severe hypertension, instability heart disease, blood diseases, liver and kidney Dysfunction; (2) suffering from sexual the organic encephalopathy or other central nervous system diseases; (3) poor adherence or uncooperative patients stop testing, replacement subjects; off the results of the patient does not participate plus evaluation and analysis; effects are not satisfied, the patient early termination of taking drugs, not to replace the cases, the patient should be Do efficacy analysis; patients because of adverse reactions to terminate the test, the results for the evaluation and analysis of adverse; Brain tissue of patients with epilepsy surgery exclusion criteria: (1) serious organic disease such as cancer, severe high blood pressure, the instability heart, blood disorders, liver and kidney dysfunction; (2) suffering from sexual the organic encephalopathy or other central nervous system diseases; (3) poor compliance or uncooperative patients stopped the trial, change the subject.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SNPs;miRNA;LncRNA; | — |
Countries
China
Contacts
Public ContactZhaoqian Liu
Outcome results
None listed