Liver cancer, pancreatic cancer, lung cancer, gastric cancer and esophageal cancer
Conditions
Interventions
Sponsors
The 81st Hospital of People’s Liberation Army
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteriafor liver cancer, pancreatic cancer, lung cancer, gastric cancer and esophageal cancer (common part): 1) Aged 18-75 years old; male or female patients; 2) Histopathological examination confirmed the diagnosis of cancer, and needs systematic anticancer therapy; 3) Can obtain fresh tumor tissues or pleural effusion or ascites samples by surgical resection or biopsy; 4) With tumor foci meeting the RECIST 1.1 standard; can evaluate the efficacy by CT/MRI; 5) ECOG PS 0-1; expected survival = 3 months; 6) Voluntary to participate and sign informed consent document; compliance is good, can actively treat and cooperate with follow-ups. Supplementary part: liver cancer:Patients with advanced hepatocellular carcinoma, to investigate the effect of As2O3, oxaliplatin and sorafenib. Pancreatic cancer: Patients with advanced pancreatic cancer, to investigate the effect of gemcitabine, oxaliplatin and Nab-paclitaxel; Not receiving radiotherapy and chemotherapy before operation; Clinical examination did not find other tumor disease; Karnofsky score=60; Bone marrow hematopoietic function is normal. lung cancer: Adjuvant therapy for stage II~IIIA non-small cell lung cancer (including adenocarcinoma, squamous cell carcinoma); Systemic treatment of locally advanced and / or metastatic non small cell lung cancer; Clinical examination did not find other tumor disease; expected survival =12weeks. Gastric cancer: Gastric cancer was confirmed by histopathology; Can obtain fresh tumor tissue specimens (surgery, endoscopy, puncture) or ascites samples. Esophageal cancer: Esophageal squamous cell carcinoma was confirmed by histopathology; Can obtain fresh tumor tissue specimens (surgery, endoscopy, puncture) or ascites samples.
Exclusion criteria
Exclusion criteria: NA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Establish PDX model database; | — |
Countries
China
Contacts
Public ContactShukui Qin
The 81st Hospital of People's Liberation Army
Outcome results
None listed