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A study of the relationship between CYP1A1 and CYP3A5 genes polymorphisms and effect of granisetron for preventing postoperative nausea and vomiting after gynecological laparoscopic operation

A study of the relationship between CYP1A1 and CYP3A5 genes polymorphisms and effect of granisetron for preventing postoperative nausea and vomiting after gynecological laparoscopic operation

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-RNC-16010044
Enrollment
Unknown
Registered
2016-11-29
Start date
2017-01-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative nausea and vomiting

Interventions

Wild-type homozygous group:The observation of blood concentration and clinical efficacy after intravenous granisetron.
Heterozygous group:The observation of blood concentration and clinical efficacy after intravenous granisetron.
Mutant homozygous group:The observation of blood concentration and clinical efficacy after intravenous granisetron.

Sponsors

Second Affiliated Hospital Harbin Medica University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. The ASA grade I-II; 2. Aged 18 to 50 years old; 3. The BMI<30kg/m2; 4. Laparoscopic surgery gynaecology teratoma, hysteromyoma, ovarian cyst, etc.

Exclusion criteria

Exclusion criteria: 1. A serious disease of cardiac and head blood-vessel dysfunction; 2. The liver and kidney dysfunction; 3. Severe gastrointestinal disease; 4. Dizzy movement disorder; 5. History of postoperative nausea and vomiting; 6. Smoking history for a long time.

Design outcomes

Primary

MeasureTime frame
Nausea and vomiting frequency, degree and grading.;VAS score and analgesia of extra time, drug and dose.;the blood concentration of granisetron;CYP1A1 (*2A, *2C), CYP3A4 (*1B, *22), CYP3A5 (*3) and for ABCB1 (rs2032582;—

Countries

China

Contacts

Public ContactLIN XUE

Second Affiliated Hospital Harbin Medica University

2443837460@qq.com+86 13796674236

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026