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Genetic polymorphisms affect therapeutic efficacy of Pioglitazone in Chinese Patients with type 2 diabetes

Genetic polymorphisms affect therapeutic efficacy of Pioglitazone in Chinese Patients with type 2 diabetes

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-RNC-12001949
Enrollment
Unknown
Registered
2012-02-15
Start date
2008-07-31
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

diabetes

Interventions

1:none

Sponsors

The Third Xiangya Hospital, Central South University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: All subjects were evaluated through medical histories, physical examinations and routine clinical laboratory tests. T2DM was diagnosed in accordance with World Health Organization criteria in 1999 by fasting plasma glucose test (FPG) >=7.0 mmol/l and/or 2h postprandial plasma glucose test (PPG) >=11.1 mmol/l. The inclusion criteria were as follows: body mass index (BMI) between 19 and 30 kg/m2 and without administration of any insulin secretagogue, agonist and inhibitor of CYP2C8, CYP3A4 (such as rifampin, glitazones, gemfibrozil, antiviral drugs, anti-eumycete drugs, and glucoconicoids) in the past 3 months.

Exclusion criteria

Exclusion criteria: Subjects with type 1 diabetes mellitus, a history of ketoacidosis, ischemic heart disease, congestive heart failure, kidney, liver diseases or alcohol abuse, patients receiving insulin treatment or other drugs which affect glucose metabolism (such as glucocorticoids) and pregnant or lactating were excluded from this study.

Design outcomes

Primary

MeasureTime frame
blood sugar;

Secondary

MeasureTime frame
blood lipids;

Contacts

Public ContactZhao-Qian Liu
liuzhaoqian63@126.com+86 13787797720

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026