infection
Conditions
Interventions
1:I.V. linezolid according to body weight, 10mg/Kg
Sponsors
Ministry of Science and Technology
Eligibility
Sex/Gender
Male
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. fully understand the content of trial and possible adverse reactions. Be voluntary to participate in this clinical trial and sigh the written informed consent form; 2. men, healthy, 18~45 years old; 3. low weight group between 50kg and 55kg, high weight group more than 80kg; 4. No heart, liver, kidney, gastrointestinal tract, nervous system, metabolic disorders and other medical history; 5. no drug and food allergies, no tobacco and alcohol addiction; 6. at least 4 weeks without taking any other drugs; 7. through medical history taking, physical examination, vital signs, clinical laboratory tests, chest X-ray examination, 12 lead ectrocardiogram confirmed health; 8. has probable compliance and very likely to complete the study.
Exclusion criteria
Exclusion criteria: 1. through medical history taking, physical examination and laboratory tests, prove that subjects suffering from any disease and tuberculosis, family history, a history of past or current history; after the review of laboratory data and comprehensive physical examination, find that Subjects have clinically significant abnormalities; 2. systolic blood pressure lower than 90 mm Hg or higher 140 mm Hg. diastolic blood pressure higher than 90 mm Hg; 3. suffer from anemia or other blood diseases, bleeding disorders, not healed trauma; 4. have a personal or family history of autoimmune disease or a history of allergies; 5. directly involved in the study of the clinical trials unit and their families; 6. have blood donation within one month before the study, or intend to do it within one month after the end of the study; 7. consume more than 28 units of alcohol (1 unit = 285ml of beer or 25ml spirits or 1 glass of wine) weekly; smoke more than five cigarettes per day (or the same amount of tobacco); drink alcoholic beverages within 48 hours before Study Day 1; 8. receive study drug within 3 months before screening period; be using or used any prescription or buy their own drugs (including corticosteroids, etc.) within 4 weeks before receiving study drug; 9. for any reason, researchers deem that the subject can not complete the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vd;CL;Tmax;AUC;Ka;Ke;t1/2;Cmax; | — |
Countries
China
Contacts
Public ContactYun Cai
Outcome results
None listed