hyperuricemia
Conditions
Interventions
group treated with Febuxostat Tablets :patients treated with Febuxostat Tablets
control group:patients treated without Febuxostat Tablets
Sponsors
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. The subject or the responsible guardian signs the informed consent; 2. Aged 18 to 75 years old; 3. Hyperuricemia (serum uric acid level in men and postmenopausal women> 420umol/L, premenopausal women> 360umol/L); 4. Allows the use of angiotensin converting enzyme inhibitors antihypertensive drugs, statins and fibrates lipid-lowering drugs, the baseline should be stable before the dose = 4 weeks; 5. Women of childbearing age who carry out contraceptive measures.
Exclusion criteria
Exclusion criteria: 1. Subjects are allergic to test drugs; 2. Lactation or pregnant women or plan a pregnancy; 3. Use of acid lowering treatment within 2 weeks; 4. Past diabetes history (history of diabetes history or use of hypoglycemic drugs) and recent high blood glucose levels (HbA1c> 7%) or fasting blood glucose> 9.0mmol/L; 5. Blood GAD-Ab, IA2-Ab positive; 6. In the past 5 years there is any systematic malignancy history; 7. Liver disease during active stage or abnormal liver function (ALT, AST, TBIL is more than 3 times the upper limit of normal); or history of cirrhosis, decompensated liver cirrhosis, or a history of hepatic encephalopathy; 8. Have a history of alcohol abuse, drug use or illicit drug use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood biochemical tests;ultrasound; | — |
Countries
China
Contacts
Public ContactHaibing Chen
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Outcome results
None listed