postoperative cognitive dysfunction
Conditions
Interventions
POCD grouo and non-POCD group:N/A
Sponsors
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. ASA 1-3; 2. Without serious heart and lung diseases, liver and kidney function damage before operation; 3. No preoperative mental disease history; 4. No history of preoperative administration of anxiolytic, antidepressant, antipsychotic drugs; 5. Expected operation time more than 4 hours; 6. More than 60 years; 7. Have good communication skills, basic language and writing skills; 8. the score is more than 23 points of mini mental state examination before anesthesia.
Exclusion criteria
Exclusion criteria: 1. Less than 60 years of age; 2. With heart disease and other serious disease; 3. With Psychiatry and Mental disease; 4. Adminintration of antidepressant, antianxiety and diazepam history before operation; 5. Operation time less than 4 hours; 6. Without good communication; 7. The score is lower than 23 points of mini mental state examination before anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IGF-1;IGFBP; | — |
Countries
China
Contacts
Public ContactHong Jiang
Outcome results
None listed