end-stage hip and knee joint non-inflammatory disease
Conditions
Interventions
TKA group:total knee joint arthroplasty
THA group:total hip joint arthroplasty
Sponsors
West China hospital, Sichuan University
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years old, normal consciousness, can understand the purpose and score of this study and sign the informed consent, not take NSAIDS, COX-2 specific inhibitor and hormone at least 2 weeks before admission; 2. A diagnosis of non infectious arthritis of hip or knee(hip: osteoarthritis, avascular necrosis of the femoral head, developmental dysplasia of the hip; knee: osteoarthritis); 3. Preoperative blood ESR, C reactive protein were normal; 4. No allergic to the COX-2 specific inhibitor, sulfonamides, NSAIDS, opioid or paracetamol / acetaminophen; 5. Accept primary, unilateral, elective total hip or knee arthroplasty in our hospital and the operation was performed by the same senior joint surgeon.
Exclusion criteria
Exclusion criteria: 1. Younger than 18 years or older than 75 years old, psychiatric or neurological or mental drugs was used currently; 2. Septic arthritis, joint arthroplasty following fracture, emergency operation, bilateral arthroplasty and revision operation, etc.; 3. Preoperative blood ESR, C reactive protein was higher than the reference value; 4. Allergic to the COX-2 specific inhibitor, sulfonamides, NSAIDS, opioid or paracetamol / acetaminophen; 5. Without control of chronic disease, clinical disease, or the researchers estimate that it may hinder the execution or affect the results of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain score;ESR;CRP;IL-1 beta;IL-6;PCT;LDH;AST;TNF alpha;CK;myoglobin;hip and knee function evaluation;local skin temperature; | — |
Countries
China
Contacts
Public ContactShen Bin
West China hospital, Sichuan University
Outcome results
None listed