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Correlation between GR in peripheral blood mononuclear cells and steroid resistance in idiopathi nephrotic syndrome: a prospective cohort study

Correlation between GR in peripheral blood mononuclear cells and steroid resistance in idiopathi nephrotic syndrome: a prospective cohort study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-RCH-13003503
Enrollment
Unknown
Registered
2013-08-22
Start date
2013-10-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Idiopathic nephrotic syndrome

Interventions

1:Glucocorticoid
2:TacroliMus

Sponsors

The First Affiliated Hospital of Dalian Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1) Aged 18-70 years old; (2) Primary nephrotic syndrome and no application of glucocorticoid or immunosuppressive agents; (3) Blood pressure can effectively control less than 130/80mmHg or without hypertension; (4) Taking an ARB or ACEI drugs more than four weeks; (5) eGFR>=60ml/min/1.73m^2; (6) Routine renal biopsy.

Exclusion criteria

Exclusion criteria: (1) All kinds of secondary nephrotic syndrome, such as lupus nephritis, Henoch-Schonlein purpura nephritis, diabetic nephropathy, hypertensive nephropathy and so on; (2) BMI=25; (3) The patients participating the other trials; (4) Researchers consider the patients not suitable for clinical trials.

Design outcomes

Primary

MeasureTime frame
GRa/ß in PBMC;Serum IL-8 Level and GRa/ß in PBMC;—

Secondary

MeasureTime frame
Cumulative remission rate;Kidney survival;Relaps;—

Countries

China

Contacts

Public ContactXie Hua
wlciq007@163.com+86 15541191277

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026