Advanced breast cancer
Conditions
Interventions
Case series:Pharmacological interventions
Sponsors
First Affiliated Hospital of Zhejiang University
Eligibility
Sex/Gender
Female
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: Aged 20 to 75 years; ECOG performance status of 0 to 2; Pathological examination confirmed the presence of breast cancer recurrence/metastasis; With at least one measurable lesion (bone metastases, ascites and pleural effusion is not considered measurable lesions);Bone marrow, kidney and liver functions are normal; Expected survival time of at least 6 months; Had received prior anthracycline and taxane chemotherapy but without vinblastine, platinum-based drugs.Submitted a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. Fluoropyrimidine drug allergies; 3. History of organ transplants; 4. Long-term use of systemic corticosteroids treatment history; 5. Current or previous history of brain tumor metastasis; 6. Serious concurrent diseases such as severe liver disease (such as cirrhosis), kidney disease, lung disease, or uncontrolled diabetes; 7. Observe significant ECG abnormalities or clinical manifestations of an apparent heart disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene mutations;TTP;PFS;OS;CR+PR; | — |
Secondary
| Measure | Time frame |
|---|---|
| toxicity; | — |
Countries
China
Contacts
Public ContactShen Peng
Medical oncology, First Affiliated Hospital of Zhejiang University
Outcome results
None listed