Functional mitral regurgitation secondary to ischemic cardiomyopathy and non-ischemic cardiomyopathy
Conditions
Interventions
1:percutaneous transluminal coronary intervention
2:Coronary artery bypass flow operation
1:Coronary artery bypass flow operation
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. FMR secondary to ischemic cardiomyopathy cases: those with previous history of myocardial infarction and/or electrocardiographic changes of ischemic heart disease were enrolled in the study; 2. FMR secondary to non-ischemic mitral regurgitation cases: non-ischemic heart disease including dilated cardiomyopathy characterized by a low ejection fraction and increased ventricular volume, and at the time of, enrollment AND all of the following: 1) Stable optimal pharmacologic therapy; 2) Sinus rhythm by ECG (including bundle branch block and first degree heart block with PR < 250 ms.)
Exclusion criteria
Exclusion criteria: 1. Patients with chronic kidney disease and chronic obstructive pulmonary disease were excluded from the study; 2. Subjects with an implanted pacemaker or ICD device; 3. Coronary artery bypass graft surgery or percutaneous coronary intervention (balloon and/or stent angioplasty); 4. Subjects with second or third degree heart block; 5. Women who are pregnant or plan to become pregnant during the course of the trial; 6. Reversible non-ischemic cardiomyopathy such as acute viral myocarditis or discontinuation of alcohol in alcohol-induced heart disease; 7. Subjects with chronic atrial fibrillation within one month prior to enrollment; 8. Presence of any disease, other than the subject's cardiac disease, associated with a reduced likelihood of survival for the duration of the trial, e.g., cancer, uremia (blood urea nitrogen [BUN] > 70 mg/dl or creatinine > 3.0 mg/dl), liver failure, etc.; 9. Subjects participating in any other clinical trials; 10. Subjects unwilling or unable to cooperate with the protocol or unwilling to sign the consent for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mitral regurgitation volume;aortomitral angle;myocardial strain;peak time of myocardial strain;cardiac volume;cardiac ejection fraction;annular displacement;Cardiac synchronization index;heart mass;left ventricular sphericity index;jet contracta area; | — |
Secondary
| Measure | Time frame |
|---|---|
| myocardial performance idex;dimension of heart chamber;area of mitral annulus;area of mitral valves;valve‘s coaptation index; | — |
Contacts
Public ContactLi Rao
West China Hospital, Sichuan University
Outcome results
None listed