acute mountain sickness
Conditions
Interventions
Inhaled Budesonide empty bottle,the same dosage as Inhaled Budesonide.
Oral Dexamethasone:Oral Dexamethasone 4mg BID
Inhaled Budesonide empty bottle, the same dosage as Inhaled Budesonide.
Placebo:Oral placebo,the same dosage as dexamethasone
Inhaled Budesonide:Inhaled Budesonide 200ug BID
Oral placebo, the same dosage as dexamethasone.
Sponsors
Institute of Cardiovascular Diseases of PLA, Xinqiao Hospital, Third Military Medical University, Chongqing, China
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 35 years, including 18 and 35 years;2. People acutely ascending to high altitude. The gender ratio depends on actual situation;3. Before assessment, all subjects must be voluntary and sign a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Subjects with high altitude exposure or preconditioning intervention history within the past 6 months; 2. Subjects with psychological or neurological disorder; 3. Subjects who cannot take the drugs in our trial because of allergic history or other reasons; 4. Subjects with bad compliance; 5. Subjects with serious illnesses; 6. Subjects with other conditions which are not appropriate for our trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lake Louise Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart Rate;blood pressure;oxygen saturation;blood biochemistry;ECG;UCG;pulmonary function;Neurobehavioral Core Test Battery;vascular endothelial function;sleep quality;SCL-90; | — |
Countries
China
Contacts
Public ContactHuang Lan
Outcome results
None listed