delayed extubation patients after craniotomy
Conditions
Interventions
Dex group:Dex group:Dexmedetomidine group patients received a continuous infusion of 0.6µg/kg/h(10ug/ml).
Saline group:Saline group:Placebo group patients received a maintenance infusion of 0.9% sodium chloride for injection at a volume and rate equal to that of dexmedetomidine.
Sponsors
ICU, Beijing Tiantan Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: All patients after intracranial surgery delayed extubation admitted to our intensive care units are screened daily for study eligibility. Patients are deemed eligible for this study if they are >=18-year old, present with an GCS-M score higher or equal than 5 in 2hr(Time Zero would be the time of ICU dmission).
Exclusion criteria
Exclusion criteria: Exclusion criteria are: patients suffering from liver insufficiency, renal insufficiency, heart rate (HR) less than 50bpm, systolic blood pressure (SBP) less than 90 mm Hg, acute myocardial infarction, second- or third degree atrioventricular block or need continuous infusions of vasopressor before the start of study drug infusionpatients suffering from consciousness disorders or epilepsy before intracranial surgery, patients suffering from Pre-existent dysphagia and cough reflex difference, patients with emergency operation or readmitted to ICU after randomization to the studypatients enrolled in another trial, pregnant or lactating women are not included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean percentages of time in optimal sedation; | — |
Secondary
| Measure | Time frame |
|---|---|
| The percentage of patients requiring propofol for rescue to achieve/ maintain targeted sedation (SAS);The effects of dexmedetomidine on haemodynamic and recovery responses during extubation;vital signs various and adverse events;Plasma levels of epinephrine, norepinephrine, dopamine,cortisol, NSE and S100-? were detected at before and after takeing medicine at hour 2, 4, 8 and the end of the study; | — |
Countries
China
Contacts
Public ContactJian-Xin Zhou
Outcome results
None listed