Acute spontaneous supratentorial intracerebral hemorrhage
Conditions
Interventions
Group B:conventional therapy+placebo
Group A:conventional therapy+oral sodium valproate 500mg daily for 7 days(temporary alternative therapy with 400mg by intravenous infusion in 250ml 0.9% normal saline)
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >18 years of age; 2. Diagnosis of spontaneous supratentorial ICH identified by CT; 3. Admission within 72 hours from ictus; 4. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. ICH secondary to trauma, tumor or infarct; 2. Early death (defined as death within 3 days of presentation); 3. Prior mRS>=3 or dementia; 4. Know seizure history on chronic AEDs; 5. Prior seizure from onset; 6. Elevated liver enzymes(three times normal); 7. Known allergy to sodium valproate; 8. Pregnant or lactating woman Pregnancy or current incarceration.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Seizure onset; | — |
Secondary
| Measure | Time frame |
|---|---|
| hematoma enlargement and midline shift;Gos and mRS score of 7 day, 3 and 6 month; | — |
Countries
China
Contacts
Public ContactChao You, Ming Liu
Outcome results
None listed