Chronic Obstructive Pulmonary Disease (COPD)
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Male and female aged of 40 years or older; 2. Written informed consent obtained; 3. Residents in these two communities, Guangzhou city; 4. Residents received a baseline screening survey in September 2002; 5. Ability to perform an acceptable spirometry and complete questionnaires.
Exclusion criteria
Exclusion criteria: 1. Accompanying with active tuberculosis, asthma or obvious bronchiectasisa, cystic fibrosis, interstitial lung disease, or pulmonary thromboembolic disease; 2. Accompanying with malignant tumor; 3. History of thoracotomy with pulmonary resection; 4. Uncontrolled or very serious cardiovascular, endocrine, blood, mental diseases, or nervous system disorders; 5. Uncontrolled condition with COPD exacerbation level; 6. Participating in any other investigational drug study within the trial period; 7. Bad compliance, judged by the investigators, not to be appropriate for inclusion in the trial; 8. Life expectancy less than 4 years; 9. Others situation that may have influence on the results of the study or the patient's ability to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Annual decline in pre-bronchodilator FEV; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvements in awareness of COPD and related risk;Annual decline in pre-bronchodilators FEV1 between smokers and no smokers;Quality of life assessment (scores of SF-12);Changes of related risk factors from baseline, i.e;Comparisons of the incidence rate and case fatality; | — |