rabies
Conditions
Interventions
Trial :rabies vaccine with 5 injections at day 0, 3, 7, 14, 28
Trial :rabies vaccine with 4 injections at day 0 (twice a day), 7, 21
Control :rabies vaccine with 5 injections at day 0, 3, 7, 14, 28
Sponsors
Hubei provincial center for disease control andprevention
Eligibility
Sex/Gender
All
Age
10 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Healthy permanent residents aged 10- 50 years; 2. Agree to participate the trial, andsigned the informed consent form; 3. The subjects andtheir guardians can comply with the requirements of clinical trial scheme; 4. Subjects has no history of rabies vaccine inoculation; 5. Subjects has no history of other vaccine , antiserum andimmunoglobulin preparations in the past 1 month; 6. the axillary temperature <=37.0 degree C.
Exclusion criteria
Exclusion criteria: 1. Have allergies, convulsions, epilepsy, encephalopathy andpsychiatric medical history or epilepsy family history; 2. Allergy to the main ingredients of the vaccine; 3. Subjects with known immunodeficiency or splenectomy; 4. Subjects had high fever (axillary temperature>38.0 degree C or higher) in the past three days; 5. Congenital malformations, developmental disorders,severe chronic diseases,severe cardiovascular diseases, diabetes, unstable hypertension cannot controlled by drugs, liver andrenal diseases andmalignant tumors, etc; 6. Subjects with acute andchronic infectious diseases,active infection,severe asthma andinfectious dermatosis, etc.; 7. Pregnancy women or breastfeeding women; 8. Any situation which the researchers think that may affect test evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adverse reaction rate;the antibody concentration of rabies virus; | — |
Countries
China
Contacts
Public ContactFaxian Zhan
Outcome results
None listed