malignant tumor
Conditions
Interventions
Strain surveillance:drug therapy
Routine echocardiograpy:drug therapy
Sponsors
Affiliated Hospital of Jiangsu University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients actively undergoing chemotherapy at increased risk of cardiotoxicity; use of anthracycline WITH current (but not necessarily concurrent) rastuzumab (Herceptin) in breast-cancer with the HER2 mutation OR tyrosine kinase inhibitors (eg sunitinib) OR cumulative anthracycline dose >450g/m2 of doxorubicin, or equivalent other anthracycline cumulative dose (eg for epirubicin >900g/m2). OR increased risk of HF (any two of age >65y, type 2 diabetes mellitus, hypertension, previous cardiac injury eg. myocardial infarction); 2. Live within a geographically accessible area for follow-up; 3. Are able and willing to provide written informed consent to participate in the study (this includes the ability to communicate fluently with the investigator and that the patient is mentally competent).
Exclusion criteria
Exclusion criteria: 1. Unable to provide written informed consent to participate in this study; 2. Participating in another clinical research trial where randomized treatment would be unacceptable; 3. Valvular stenosis or regurgitation of >moderate severity; 4. History of previous heart failure (baseline NYHA >2); 5. Systolic BP <110mmHg; 6. Pulse <60/minute; 7. Inability to acquire interpretable images (identified from baseline echo); 8. Contraindications/Intolerance to beta blockers or ACE inhibitors; 9. Existing therapy with both beta blockers and ACE inhibitors; 10. Oncologic (or other) life expectancy <12 months or any other medical condition (including pregnancy) that results in the belief (deemed by the Chief Investigators) that it is not appropriate for the patient to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| myocardial strain;cardiac function; | — |
Countries
China
Contacts
Public ContactYan Jin-Chuan
Affiliated Hospital of Jiangsu University
Outcome results
None listed