eosinophilic granuloma
Conditions
Interventions
Surgical group:Surgical treatment of decompression with instrumentation, chemotherapy and adjuvant therapy.
Control group:chemotherapy and adjuvant therapy
Sponsors
Shanghai Changzheng Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 15 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria include the pediatric patients younger than 15 years old with pathological diagnosis of spinal eosinophilic granuloma, and had primary treatment in our institution. Their epiphyseal plate should be premature and the structure of vertebral body are destroyed by the imaging examinations (including magnetic resonance imaging (MRI) and computed tomography (CT)).
Exclusion criteria
Exclusion criteria: Exclusion criteria include the patients with non-spine lesions or systematic Langerhans cell histiocytosis (LCH), without pathological diagnosis of eosinophilic granuloma, older than 15 years old or with epiphyseal plate closure under imaging examinations. Patients with serious spinal cord compression or spinal instability, who cannot have conservative treatment, or with the contraindications of surgical treatment are not included in our study. The patients who have poor compliance with incomplete chemotherapy, have primary treatment elsewhere, are participating other randomized controlled trials (RCT), or loss to follow-up are also excluded from our study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| central height of vertebral body;length of vertebral pedicle;sagittal diameter of spinal canal;transverse diameter of spinal canal;Cobb's angle;VAS scale;Oucher scale;Frankel scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| height;bone maturity;use of analgesics;duration of immobilization. ; | — |
Countries
China
Contacts
Public ContactJianru Xiao
Shanghai Changzheng Hospital
Outcome results
None listed