postoperative cognitive dysfunction
Conditions
Interventions
ACEI treating cohort versus non ACEI cohort:Elective non cardiac surgery
Sponsors
Ningbo 2nd Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. No less than 65 years; 2. Past history of hypertension, taking antihypertensive drugs regularly for no less than 1 month; 3. Non-cardiac surgery; 4. No history of injury or history of surgery in 3 months. 5. With Hb no less than 70g/L; 6. Informed consent.
Exclusion criteria
Exclusion criteria: 1. History of depression or cognitive impairment; 2. drug abuse, alcohol abuse, long-term use benzodiazepine drugs or antidepressants; 3. Hearing or visual impairment; 4. History of cardiovascular cerebrovascular accident with neurological sequelae within 6 months; 5. History of previous cardiovascular or central nervous system surgery; 6. Emergency surgery; 7. Being participated in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of POCD;ACE activity;Ace genotype; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative complications; | — |
Countries
China
Contacts
Public ContactChen Junping
Ningbo 2nd Hospital
Outcome results
None listed