schizophrenia
Conditions
Interventions
risperidone reduction group:risperidone dose reduced by 50% and then maintained
risperidone maintenance group:risperidone dose kept constant
Sponsors
Guangzhou Brain Hospital (Guangzhou Huiai Hospital, The Affiliated Brain Hospital of Guangzhou Medical University)
Eligibility
Sex/Gender
All
Age
16 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1. diagnosed with schizophrenia according to DSM-IV; 2. aged from 16 to 59; 3. maintained a stable clinical state for at least 3 months, and in remission with respect to positive symptoms, as defied by a score of =3 (mild) on all of the following 4 Positive and Negative Syndrome Scale (PANSS) 8 Positive subscale items: delusion (P1), conceptual disorganization (P2), hallucinatory behavior (P3), and suspiciousness (P6); 4. receiving a stable dose of either risperidone =5mg/day as antipsychotic monotherapy for at least 3 months. Patients on antipsychotic polypharmacy were excluded, although concomitant use of =50 mg/day of clozapine or <=200 mg/day of quetiapine was allowed; 5. ethnic Han; 6. wrote informed consent.
Exclusion criteria
Exclusion criteria: 1. suffered from any signifiant medical or neurological illnesses; 2. had a history of alcohol/substance misuse within the 12 months prior to participation; 3. had a history of ECT within the 6 months prior to participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| risk of relapse;cognitive function; | — |
Countries
China
Contacts
Public ContactZhou Yanling
Outcome results
None listed