Kaschin-Beck Disease
Conditions
Interventions
Control group:no intervention
Replacing grain group:150 kg of rice from non-KBD areas
selenium supplementation group:7 kg of selenium-iodine salt
Combined group:150 kg of rice from non-KBD areas and 7 kg of selenium-iodine salt
Sponsors
Harbin Medical University
Eligibility
Sex/Gender
All
Age
6 Years to 12 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria included children aged 6-11 years, children who lived in our test sites > 3 years, patients with KBD who had important clinical signs and symptoms, such as joint thickening, joint pain, joint deformity, muscle weakness, limitation of motion and muscle atrophy, and children who were diagnosed and graded according to the Chinese Radiological Criteria of Kashin-Beck Disease Diagnosis (GB16003-1995).
Exclusion criteria
Exclusion criteria: Children with other joint diseases, such as joint inflammation, metabolic bone diseases, neoplasia, osteoporosis, and osteomalacia, as well as those who declined to join the survey, were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The X-ray-positive rate;The repair rate of metaphyseal changes;The proportion of new case; | — |
Secondary
| Measure | Time frame |
|---|---|
| The content of selenium in hair; | — |
Countries
China
Contacts
Public ContactLi-Hua Wang
Outcome results
None listed