acute coronary syndrome
Conditions
Interventions
A group:atorvastatin 40mg/d for 1 month and then with atorvastatin 20mg/d to maintain until LDL-C<2.07mmol/L
B group:atorvastatin 40mg/d for 1 month and then with atorvastatin 20mg/d to maintain until LDL-C<2.07mmol/L and hs-CRP<3mg/L
Sponsors
Pudong New Area District Zhoupu Hospital, Shanghai
Eligibility
Sex/Gender
All
Age
38 Years to 86 Years
Inclusion criteria
Inclusion criteria: (1) Unstable Angina: The new onset or the worse angina over the previous 1 month at the time of presentation coinciding with appropriate objective evidence of myocardial ischemia in ECG or myocardial perfusion imaging. At least 1 de novo lesion with >50% stenosis was founded by coronary angiography (CAG); (2) Acute Myocardial Infarction: The chest pain lasted more than 30 minutes and the levels of troponin-T and creatine kinase muscle B (CK-MB) was more than 3 times the upper limit of normal with or without ST-segment elevation. Plaque rupture and thrombosis were confirmed by CAG.
Exclusion criteria
Exclusion criteria: (1) Previous myocardial infarction; (2) Previous stroke; (3) Previous revascularization; (4) Hepatic dysfunction or renal dysfunction; (5) Complicated with malignant tumor or severe organ failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| high-sensitivity C-reactive protein, hs-CRP;low-density lipoprotein cholesterol, LDL-C; | — |
Secondary
| Measure | Time frame |
|---|---|
| Alanine aminotransferase, ALT;cardiac troponin I, cTnI;creatinine kinase, MB isoenzyme, CK-MB;creatinine kinase, CK;Myoglobin, Mb;serum creatinine;electrocardiogram, ECG;Percentage of coronary artery stenosis; | — |
Countries
China
Contacts
Public ContactFANG Ming
Outcome results
None listed