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A value Study of Central venous-to-arterial carbon dioxide difference combined with arterial-to-venous oxygen content difference in the hemodynamic resuscitation process in severe sepsis

A value Study of Central venous-to-arterial carbon dioxide difference combined with arterial-to-venous oxygen content difference in the hemodynamic resuscitation process in severe sepsis

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR-PNC-16010288
Enrollment
Unknown
Registered
2016-12-28
Start date
2017-01-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe Sepsis

Interventions

Case series:Nil

Sponsors

Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged>18 years old; 2. Patients with severe sepsis or sepsis shock; 3. Hyperlactatemia (blood lactate=4mmol/L).

Exclusion criteria

Exclusion criteria: 1. Pregnancy; 2. Patients with systemic immune diseases or advanced malignancies; 3. Acute coronary syndrome or acute cerebrovascular accident; 4. Patients already show clinic symptoms of liquid high load; 5. Patients need emergency surgery; 6. Patients whose sublingual veins can not be observed because of the oral or extraneous factors; 7. Contraindication of central venous catheter or blood transfusion; 8. Patients die less than 24h from enrolling in grouph.

Design outcomes

Primary

MeasureTime frame
SOFA;—

Secondary

MeasureTime frame
PcvaCO2/CavO2;Lac;proportion of perfused vessels, PPV;microvascular flow index, MFI;—

Countries

China

Contacts

Public ContactKeji Zhang

Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University

zhangkejide@sina.com+86 13817592023

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026