Non small cell lung cancer
Conditions
Interventions
experimental group:Microfluidic sorting of tumor cells+chemotherapy
control group:chemotherapy
Sponsors
Shanghai Chest Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years old, male and female; 2. there was no late stage (stage III B and not to be treated) and metastatic (stage IV) NSCLC in the presence of an inability to be operated by histopathology or cytology; 3. patients with tumors lacking EGFR sensitive mutation (i.e. deletion of exon 19, exon 21 and exon 21 of L858R, L861Q, exon 18 or G719X exon 20 S7681 mutation) and ALK rearrangement, or the corresponding targeted drug treatment failure; 4. patients with advanced lung cancer were able to obtain fresh tumor tissue or pleural effusion samples; 5. At least 5 of 1 lesions (who had not received radiotherapy), baseline by CT accurate measurement showed the longest diameter over 10mm (lymph nodes except short axis lymph node must be greater than or equal to 15mm), and RECIST v1.1 in accordance with the guidelines, the focus for repeated measurement; 6. Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1, the expected survival should be more than 3 months; 7. signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Can not or refuse to collect tumor samples, including tumor tissue blocks, or malignant pleural effusion, or circulating tumor cells, etc.; 2. Refused to accept the relevant treatment or follow-up programs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Survival Time;Toxic and side effects; | — |
Countries
China
Contacts
Public ContactZhiwei Chen
Shanghai Chest Hospital
Outcome results
None listed