Invasive Fungal Infections
Conditions
Interventions
1:Mycamine ( Micafungin Sodium for injection) should be administered 50mg/day, Intravenous infusion, and should be taken on the first day of the transplantation/ chemotherapy, with administration peri
Sponsors
Shanghai First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 ~ 60 of either gender; 2. patients with malignant haematological disease undergoing a hematopoietic stem cell transplant or chemotherapy; 3. patient with high-risk of IFI: patient with anticipated neutropenia (absolute neutrophil count [ANC] <500 cells/mm3 )for 7 days or profound neutropenia (absolute neutrophil count [ANC] <100 cells/mm3) even application of G-CSF is also considered; 4. Patients with no history of IFI and antifungal prophylaxis; 5. Given written informed consent.
Exclusion criteria
Exclusion criteria: 1. G test positive at screening; 2. Diagnosed as IFI (including possible, probable or proven) before enrollment; 3. Pregnant woman or breast-feeding mother; 4. Elevated AST/SGOT or ALT/SGPT >5 times ULN; 5. Total bilirubin >2.5 times ULN; 6. Known allergy to echinocandin; 7. Other patients with complications who are unsuitable to be included in the trial judged by investigator; 8. Patients who is participating in another clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment successful rate at the end of treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of possible invasive fungal infection;The incidence of proven or probable invasive fung; | — |
Countries
China
Contacts
Public ContactChun. Wang
Outcome results
None listed