Chronic obstructive pulmonary disease
Conditions
Interventions
A:theophylline with tiotropium bromide inhalation
B:Tiotropium bromide inhalation
Sponsors
The Affiliated Hospital of Guangdong Medical College
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: Early stable COPD patients(GOLD grade I - II, FEV1 expected 50% or higher), 40-75 years old and with or without a cigarette smoking history and respiratory symptoms related to COPD were enrolled in the study.
Exclusion criteria
Exclusion criteria: 1. baseline blood routine, biochemical or routine urine analysis have clinically significant abnormal; 2. serious heart, liver, kidney, brain, blood or malignant tumor; 3. alcoholism, drug addiction, mental disorder and consciousness disorder; 4. drug allergy or for allergic constitution; 5. using immune modulators before and during treatment; 6. clinical diagnosis of lung cancer, bronchiectasis, pneumoconiosis, or other restrictive ventilatory disorder; 7. hyperplasia of prostate, bladder neck obstruction and appear obvious symptoms, narrow Angle glaucoma patients; 8. a history of asthma, allergic rhinitis; 9. COPD exacerbations previous 4 weeks, or need to be hospitalized during selected and/or antibiotic treatment and/or oral hormone therapy; 10. pneumonectomy or existing active TB; 11. need a long-term home oxygen therapy, often oral hormone (prednisone > 10 mg/d) or long-term use of antibiotics; 12. pregnancy; 13. engaged in another clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical assessment;lung function;quality of life;Cost effectiveness analysis;adverse event; | — |
Countries
China
Contacts
Public ContactTianwen Lai
Outcome results
None listed